To examine the association and modifiable risk factors between grip strength (GS) and Parkinson’s disease (PD) incidence considering genetic factors, a total of 411,648 individuals without PD at baseline from the UK Biobank were included. GS was measured by a hydraulic dynamometer. The polygenic risk score assessed the genetic predisposition. Multivariable Cox regression models were performed. During a median follow-up of 12.3 years, 2409 individuals developed PD. Compared with those with high GS, low-GS individuals had a 58.5% increased risk of PD (42.7%–76.1%), and 16.3% of this excess risk could be explained by adjusted risk factors. Low GS and high genetic predisposition contribute to the highest PD risk in an additive interaction. We observed that low GS was associated with higher PD incidence, particularly among individuals with high genetic predisposition. In addition to enhancing GS, interventions targeting risk factors (e.g., unhealthy lifestyles) might also reduce the excess risk.

为了检查考虑遗传因素的握力 （GS） 和帕金森病 （PD） 发病率之间的关联和可改变的危险因素，共纳入了来自英国生物样本库的 411,648 名基线时没有 PD 的个体。GS 由水力测功机测量。多基因风险评分评估了遗传易感性。执行多变量 Cox 回归模型。在中位随访 12.3 年期间，2409 人发生 PD。与高 GS 患者相比，低 GS 个体患 PD 的风险增加了 58.5% （42.7%–76.1%），其中 16.3% 的超额风险可以用调整后的风险因素来解释。在加性相互作用中，低 GS 和高遗传易感性导致 PD 风险最高。我们观察到低 GS 与较高的 PD 发生率相关，尤其是在具有高遗传易感性的个体中。除了提高 GS 外，针对风险因素 （例如，不健康的生活方式） 的干预措施也可能降低超额风险。