Resting tremor (RT) is a Parkinson’s disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson’s Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients. Furthermore, higher baseline CBR was linked to RT development. In the smaller cohorts, a 4–6 Hz oscillation-based metric from inertial sensors correlated with RT amplitude, distinguished controls from patients with reduced DaT binding and correlated with CBR in the latter group. In silico modelling uncovered that higher CBR in RT patients explained correlations between RT and DaT-SPECT found in several datasets, supporting a spurious origin for ipsilateral correlations between CBR and RT. These results suggest that caudate dopaminergic terminals integrity is a feature of RT with potential pathophysiological implications.

静止性震颤 （RT） 是一种帕金森病 （PD） 症状，与多巴胺能系统的关系尚不清楚。我们分析了来自帕金森病进展标志物倡议的 432 名受试者、57 名额外的 PD 患者和对照以及 86 名转诊接受多巴胺转运蛋白单光子发射计算机断层扫描 （DaT-SPECT） 的受试者的数据。尾状核结合比 （CBR） 高于 RT 患者的壳核结合比，但壳核结合比不高于 RT 患者。此外，较高的基线 CBR 与 RT 的发展有关。在较小的队列中，来自惯性传感器的基于 4-6 Hz 振荡的指标与 RT 振幅相关，将对照组与 DaT 结合减少的患者区分开来，并与后一组的 CBR 相关。计算机建模发现，RT 患者较高的 CBR 解释了在多个数据集中发现的 RT 和 DaT-SPECT 之间的相关性，支持 CBR 和 RT 之间同侧相关性的虚假来源。这些结果表明，尾状多巴胺能末端完整性是 RT 的一个特征，具有潜在的病理生理学意义。