Parkinson’s disease (PD) is a common neurodegenerative disease that is a growing public health challenge. Estimates of the burden of PD have focused on data from high-income countries, with lower-income countries poorly described. We reviewed and examined the prevalence of PD reported by studies in low- to upper-middle-income countries. A systematic literature search was performed in the Medline/PubMed, Embase, LILACS, and Web of Science databases. Age group, sex, and geographic region were considered when analyzing the data. Of the 4327 assessed articles, 57 met the inclusion criteria for qualitative review, and 36 were included in the meta-analysis. Heterogeneity measures were high both as a whole and in each geographic region. Data analysis by geographic region showed that reported prevalence differed across regions, ranging from 49 per 100,000 (Sub-Saharan Africa) to 1081 per 100,000 (Latin America and the Caribbean). There was an increasing prevalence of PD with advancing age (per 100,000): 7 in 40–49 years, 158 in 50–59 years, 603 in 60–69 years, 1251 in 70–79 years, and 2181 in over the age of 80. The prevalence of PD in men and women was similar. There was a greater PD prevalence in populations with a higher 5-year GDP per capita and a higher life expectancy. Our findings suggest a higher prevalence of PD in lower and upper-middle-income countries than previously reported. Comparisons between regions are difficult, as the sociocultural differences and lack of methodological standardization hinder understanding key epidemiological data in varied populations.

帕金森病 (PD) 是一种常见的神经退行性疾病，是一个日益严峻的公共卫生挑战。对PD负担的估计主要集中在高收入国家的数据，而对低收入国家的描述很少。我们回顾并检查了中低收入国家研究报告的帕金森病患病率。在 Medline/PubMed、Embase、LILACS 和 Web of Science 数据库中进行了系统的文献检索。分析数据时考虑了年龄组、性别和地理区域。在 4327 篇评估文章中，57 篇符合定性审查纳入标准，36 篇纳入荟萃分析。整体和每个地理区域的异质性指标都很高。按地理区域进行的数据分析显示，各地区报告的患病率有所不同，从每 100,000 人 49 人（撒哈拉以南非洲）到每 100,000 人 1081 人（拉丁美洲和加勒比地区）。随着年龄的增长，帕金森病的患病率也随之增加（每10万人）：40-49岁有7人，50-59岁有158人，60-69岁有603人，70-79岁有1251人，20岁以上有2181人。 80. 男性和女性的帕金森病患病率相似。五年人均 GDP 较高和预期寿命较高的人群中 PD 患病率较高。我们的研究结果表明，低收入和中高收入国家的帕金森病患病率比之前报道的要高。地区之间的比较很困难，因为社会文化差异和方法标准化的缺乏阻碍了对不同人群的关键流行病学数据的理解。