Parkinson’s Disease (PD) is a prevalent, progressive neurodegenerative disease with motor and non-motor symptoms. Vagus Nerve Stimulation (VNS) has emerged as a potential therapeutic approach for PD, but published research on this topic varies widely. This scoping review maps existing literature on VNS for PD, highlighting stimulation methods, operational parameters, safety profiles, neurophysiological mechanisms, and clinical outcomes in human and animal models. Online databases were used to identify 788 papers published between 2013 and 2023, from which 17 publications on invasive and non-invasive VNS in PD were selected. Studies showed high variability in VNS parameters and study design. Evidence in animal models and human subjects suggests potential neurophysiological effects on PD-related pathology and motor function improvements. However, significant gaps in the literature remain. Future research should include rigorous reporting of study design, standardization of stimulation parameters, and larger sample sizes to ultimately facilitate translation of VNS into clinical practice.

帕金森病 （PD） 是一种普遍的进行性神经退行性疾病，伴有运动和非运动症状。迷走神经刺激 （VNS） 已成为 PD 的一种潜在治疗方法，但关于该主题的已发表研究差异很大。本范围综述绘制了有关 VNS 治疗 PD 的现有文献，重点介绍了人类和动物模型中的刺激方法、操作参数、安全性概况、神经生理机制和临床结果。使用在线数据库确定了 2013 年至 2023 年间发表的 788 篇论文，其中 17 篇关于帕金森病侵袭性和非侵袭性 VNS 的出版物被选中。研究表明 VNS 参数和研究设计具有高度可变性。动物模型和人类受试者的证据表明，神经生理学对 PD 相关病理和运动功能改善有潜在影响。然而，文献中仍然存在重大空白。未来的研究应包括对研究设计的严格报告、刺激参数的标准化和更大的样本量，以最终促进 VNS 转化为临床实践。