Intravenous arachnoid granulations (AGs) are protrusions of the arachnoid membrane into the venous lumen and function as contributors to the cerebrospinal fluid (CSF) flow circuit. Patients with Parkinson disease (PD) often present with accumulation of alpha synuclein. Previous works have provided evidence for neurofluid circulation dysfunction in neurodegenerative diseases associated with changes in CSF egress, which may have implications regarding AG morphology. The present study aims to investigate group differences in AG volumetrics between healthy and PD participants, as well as relationships between AG characteristics and clinical assessments. Generalized linear models revealed significant increases in AG volumetrics and number in PD compared to healthy controls. Partial Spearman-rank correlation analyses demonstrated significant relationships between AG metrics and motor and cognitive assessments. Finally, AG volumetrics were positively correlated with objective actigraphy measures of sleep dysfunction, but not self-report sleep symptoms.

静脉内蛛网膜颗粒（AG）是蛛网膜向静脉腔内的突出物，其功能是脑脊液（CSF）流动回路的贡献者。帕金森病 (PD) 患者经常出现 α 突触核蛋白积聚。先前的工作已经为神经退行性疾病中与脑脊液出口变化相关的神经液循环功能障碍提供了证据，这可能对 AG 形态有影响。本研究旨在调查健康参与者和 PD 参与者之间 AG 体积的群体差异，以及 AG 特征与临床评估之间的关系。广义线性模型显示，与健康对照相比，AG 体积和 PD 数量显着增加。部分斯皮尔曼等级相关分析表明 AG 指标与运动和认知评估之间存在显着关系。最后，AG 容量与睡眠功能障碍的客观体动记录仪测量呈正相关，但与自我报告的睡眠症状无关。