Bipolar disorder (BD) is linked to an increased risk of neurodegenerative diseases such as dementia and Parkinson disease (PD), yet several uncertainties still remain and the extent to which the associations could be explained by BD-related medications (antipsychotics, lithium, and antiepileptics) was unknown. This study included 501,233 UK Biobank participants (mean [standard deviation] age, 56.5 [8.10] years; 54.4% women), free of dementia and PD at baseline. After a median 13.8 year follow-up, 9422 cases of dementia and 3457 PD cases were identified. Participants with BD had a significantly higher risk of dementia (adjusted hazard ratio [HR] 2.52, 95% CI 2.00–3.19) and PD (adjusted HR 2.88, 95% CI 2.03-4.08). Findings suggest that up to two-thirds of the association of neurodegenerative diseases with BD may be mediated by BD-related medications. Further research is needed to confirm these findings and explore the underlying mechanisms.

双相情感障碍 (BD) 与痴呆和帕金森病 (PD) 等神经退行性疾病的风险增加有关，但仍然存在一些不确定性，以及 BD 相关药物（抗精神病药、锂和抗癫痫药）未知。这项研究包括 501,233 名英国生物银行参与者（平均 [标准差] 年龄，56.5 [8.10] 岁；54.4% 为女性），基线时没有痴呆和帕金森病。经过中位 13.8 年的随访，发现了 9422 例痴呆症病例和 3457 例帕金森病病例。患有 BD 的参与者患痴呆症（调整后的风险比 [HR] 2.52，95% CI 2.00-3.19）和 PD（调整后的 HR 2.88，95% CI 2.03-4.08）的风险显着较高。研究结果表明，多达三分之二的神经退行性疾病与 BD 相关可能是由 BD 相关药物介导的。需要进一步的研究来证实这些发现并探索潜在的机制。