Individual variability exists in parkinsonian motor symptoms despite a similar degree of nigrostriatal dopamine depletion in Parkinson’s disease (PD), called motor reserve. We enrolled 397 patients newly diagnosed with PD who underwent dual-phase ¹⁸F-FP-CIT PET upon initial assessment. Individual motor reserve was estimated based on initial parkinsonian motor symptoms and striatal dopamine transporter availability using a residual model. Patients with low motor reserve (the lowest quartile group, n = 100) exhibited decreased uptake in the occipital region compared to those with high motor reserve (the highest quartile group, n = 100) on early-phase ¹⁸F-FP-CIT PET images. Patients with high motor reserve had a lower risk of conversion to dementia than the those with low motor reserve, whereas the effect of PD groups on the risk of dementia conversion was not mediated by occipital hypoperfusion. These findings suggest that cerebral hypoperfusion in the occipital region is associated with low motor reserve in patients with PD.

尽管帕金森病 （PD） 中黑质纹状体多巴胺消耗的程度相似，称为运动储备，但帕金森病运动症状仍然存在个体差异。我们招募了 397 例新诊断为 PD 的患者，这些患者在初步评估时接受了双阶段 ¹⁸F-FP-CIT PET。使用残差模型根据初始帕金森病运动症状和纹状体多巴胺转运蛋白的可用性估计个体运动储备。在早期 ¹⁸F-FP-CIT PET 图像中，与高运动储备患者 （最高四分位数组，n = 100） 相比，低运动储备患者 （最低四分位数组，n = 100） 表现出枕骨区域的摄取减少。高运动储备患者转化为痴呆的风险低于低运动储备患者，而 PD 组对痴呆转化风险的影响不是由枕骨灌注不足介导的。这些发现表明，枕部脑灌注不足与 PD 患者的低运动储备有关。