Idiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion. Between June 2021 and October 2023, twelve PD patients underwent the procedure, with primary outcomes focused on safety and motor improvements after six months. Results indicated significant motor improvements, with over 50% reduction in tremor, rigidity, and bradykinesia, while balance and gait remained stable. Quality of life also improved. Side effects were generally mild and transient, though some patients experienced involuntary movements, managed through medication adjustments. Despite limitations, this technique appears to offer a promising, less-invasive alternative for managing PD symptoms with a favorable risk-benefit profile. Further research is necessary to refine the procedure and assess long-term outcomes.

特发性帕金森病 （PD） 是一种神经退行性疾病，其特征是震颤、强直、运动迟缓和姿势不稳。磁共振引导下对丘脑底核 （STN） 的高强度聚焦超声 （MRgFUS） 作为一种微创手术选择越来越受到认可。本研究评估了单侧 MRgFUS 丘脑下切开术的安全性和有效性，旨在创造最小的有效病变。2021 年 6 月至 2023 年 10 月期间，12 名 PD 患者接受了该手术，主要结果集中在 6 个月后的安全性和运动改善上。结果表明，运动有显著改善，震颤、僵硬和运动迟缓减少了 50% 以上，而平衡和步态保持稳定。生活质量也有所改善。副作用通常是轻微和短暂的，尽管一些患者经历了不自主的运动，通过药物调整来控制。尽管存在局限性，但该技术似乎为管理 PD 症状提供了一种有前途的、侵入性较小的替代方案，具有良好的风险收益。需要进一步的研究来改进手术并评估长期结局。