Transcranial direct current stimulation (tDCS) is a promising noninvasive intervention for Parkinson’s disease (PD). However, studies of its motor and cognitive effect have produced mixed results. We conducted a systematic review including 38 studies and meta-analysis of 12 randomized sham-controlled trials with 263 PD patients. No significant differences were found between active and sham tDCS in motor function (UPDRS-III: SMD = –0.14, p = 0.74), gait (SMD = 0.10, p = 0.513), attention and working memory (SMD = 0.24, p = 0.13), executive function (SMD = 0.03, p = 0.854), and memory and learning (SMD: −0.07, p = 0.758). The prediction intervals indicated substantial heterogeneity among studies. Meta-regression showed small positive effects in younger PD patients with milder symptoms. These findings are preliminary but suggest tDCS may benefit some PD patients while being neutral or harmful to others.

经颅直流电刺激 （tDCS） 是一种很有前途的帕金森病 （PD） 无创干预措施。然而，对其运动和认知影响的研究产生了喜忧参半的结果。我们进行了一项系统评价，包括 38 项研究和对 12 项随机假对照试验的荟萃分析，涉及 263 名 PD 患者。主动和假 tDCS 在运动功能 （UPDRS-III： SMD = –0.14， p = 0.74）、步态 （SMD = 0.10， p = 0.513）、注意力和工作记忆 （SMD = 0.24， p = 0.13）、执行功能 （SMD = 0.03， p = 0.854） 以及记忆和学习 （SMD： -0.07， p = 0.758） 方面没有显着差异。预测区间表明研究之间存在很大的异质性。Meta 回归分析显示，对症状较轻的年轻 PD 患者有较小的积极影响。这些发现是初步的，但表明 tDCS 可能使一些 PD 患者受益，同时对其他人保持中立或有害。