The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on neuropsychiatric fluctuations in Parkinson´s disease (PD) remains unclear. The Neuropsychiatric Fluctuations Scale (NFS) can help to fill this gap, directly measuring fluctuations between the OFF- and ON-medication conditions. The NFS provides NFS-plus (hyperdopaminergic) and NFS-minus (hypodopaminergic) sub-scores. Based on these, the NFS global scores express the overall magnitude of neuropsychiatric symptoms in both the OFF- and ON-medication states. The total fluctuation score (TFS) represents the difference between ON- vs. OFF-medication NFS global scores, thus assessing fluctuations amplitude. The NFS was used to evaluate changes in neuropsychiatric fluctuations between the OFF- and ON-medication conditions before and 1-year after bilateral STN-DBS in 45 PD patients (32 males; mean age, 61.3 ± 7.2 years; PD duration, 10.2 ± 3.0 years). After surgery, the amplitude of neuropsychiatric fluctuations was significantly reduced (p < 0.001), confirming the efficacy of STN-DBS on these symptoms.

丘脑底核 （STN） 脑深部刺激 （DBS） 对帕金森病 （PD） 神经精神波动的影响仍不清楚。神经精神病学波动量表 （NFS） 可以帮助填补这一空白，直接测量停药和 ON用药条件之间的波动。NFS 提供 NFS-plus（高多巴胺能）和 NFS-minus（低多巴胺能）子分数。基于这些，NFS 整体评分表示 OFF 和 ON-medication 状态下神经精神症状的总体程度。总波动评分 （TFS） 表示 ON-AND OFF-medication NFS 总体评分之间的差异，从而评估波动幅度。NFS 用于评估 45 例 PD 患者 （32 名男性;平均年龄 61.3 ± 7.2 岁;PD 持续时间，10.2 ± 3.0 年）。手术后，神经精神波动的幅度显着降低 （p < 0.001），证实了 STN-DBS 对这些症状的疗效。