BackgroundTo explore the correlation between short‐chain fatty acids (SCFAs) in the peri‐implant sulcular fluid (PISF) and peri‐implant diseases.MethodsPISF samples were obtained from implants that have been placed for at least 5 years, and peri‐implant clinical parameters were examined. Gas chromatography‐mass spectrometry and high‐performance liquid chromatography were used to detect SCFAs in PISF. The correlation between SCFAs and clinical parameters was analyzed by Spearman's correlation. SCFAs related to peri‐implant disease were identified by logistic regression and ranked by random forest analysis.ResultsEighty‐six implants were divided into a peri‐implant health group (PIH‐group, 35 implants), peri‐implant mucositis group (PIM‐group, 25 implants), and peri‐implantitis group (PI‐group, 26 implants) according to clinical and radiographic examination results. The PIM‐group had significantly lower formic acid detection rate than the other two groups (p < 0.001). The PIM‐group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM‐group (p < 0.05). SCFAs (apart from hexanoic and succinic acids) were significantly and positively correlated with clinical parameters (p < 0.05). SCFAs related to peri‐implant disease were ranked as follows: butyric, isovaleric, isobutyric, propionic, acetic, formic, and lactic acids.ConclusionsElevated specific SCFAs are correlated with peri‐implant disease. Recognition of this correlation may help in early identification of peri‐implant disease and guide further clinical interventions.

中文翻译：

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短链脂肪酸与种植体周围疾病之间的相关性：横断面研究


背景探讨种植体周围龈沟液（PISF）中的短链脂肪酸（SCFA）与种植体周围疾病之间的相关性。方法从已放置至少5年的种植体中获取PISF样本，并进行种植体周围临床分析。参数进行了检查。采用气相色谱-质谱法和高效液相色谱法检测 PISF 中的 SCFA。通过Spearman相关分析SCFA与临床参数之间的相关性。通过逻辑回归确定与种植体周围疾病相关的 SCFA，并通过随机森林分析进行排名。结果 86 个种植体分为种植体周围健康组（PIH 组，35 个种植体）、种植体周围粘膜炎组（PIM 组）根据临床和放射学检查结果，种植体周围炎组（PI 组，25 个种植体）和种植体​​周围炎组（PI 组，26 个种植体）。 PIM组的甲酸检出率显着低于其他两组（ p < 0.001）。 PIM 组的乙酸、丙酸和异戊酸水平显着高于 PIH 组（ p < 0.05）。 PI组的丙酸、丁酸、异丁酸、戊酸和异戊酸水平显着高于PIH组（ p < 0.05）。 PI组的丁酸、异丁酸和异戊酸水平显着高于PIM组（ p < 0.05）。 SCFA（除了己酸和琥珀酸）与临床参数显着呈正相关（ p < 0.05）。与种植体周围疾病相关的 SCFA 排序如下：丁酸、异戊酸、异丁酸、丙酸、乙酸、甲酸和乳酸。结论特定 SCFA 升高与种植体周围疾病相关。认识到这种相关性可能有助于早期识别种植体周围疾病并指导进一步的临床干预。