BackgroundTo compare bone regeneration and dimensional alteration of alveolar ridge at intact and damaged extraction sockets after alveolar ridge preservation (ARP) and implant placement versus unassisted socket healing followed by guided bone regeneration (GBR) with simultaneous implant placement.MethodsIn 6 beagle dogs, 3 types of extraction sockets in the mandible were created: (1) intact sockets, (2) 1‐wall defect sockets and (3) 2‐wall defect sockets. The sockets were allocated to undergo either (1) ARP and implant placement 8 weeks later (ARP group) or (2) GBR with simultaneous implant placement after 8 weeks of unassisted socket healing (GBR group). After an additional healing period of 8 weeks, bone regeneration and dimensional changes were evaluated radiographically and histologically.ResultsGBR showed superior bone formation and greater bone gains compared to ARP, regardless of the initial extraction‐socket configuration. Although ARP maintained the preexisting alveolar ridge dimensions, peri‐implant bone defects were still detected at 8 weeks of follow‐up. Histomorphometric analyses confirmed that GBR increased dimensions of the alveolar ridge compared to baseline, and the augmentation and bone regeneration were greater with GBR than with ARP.ConclusionEarly implant placement with ARP can mitigate alveolar ridge changes in the narrow alveolar ridge. However, early implant placement with simultaneous GBR creates the conditions for enhanced bone regeneration around the implant and greater ridge augmentation compared to ARP, irrespective of the extraction‐socket configuration.

中文翻译：

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比较窄牙槽嵴完整和受损部位无辅助牙槽窝愈合后牙槽嵴保存与引导骨再生的体内实验研究


背景比较保留牙槽嵴 (ARP) 和种植体植入后完整和受损拔牙槽的骨再生和牙槽嵴尺寸变化与无辅助牙槽窝愈合，然后引导骨再生 (GBR) 同时植入种植体。方法在 6 只比格犬中，3 种类型创建了下颌骨中的拔牙窝：（1）完整的窝，（2）1壁缺陷窝和（3）2壁缺陷窝。牙槽窝被分配接受 (1) ARP 和种植体植入 8 周后（ARP 组）或 (2) GBR 并在 8 周无辅助牙槽愈合后同时植入种植体（GBR 组）。经过 8 周的额外愈合期后，通过放射学和组织学评估骨再生和尺寸变化。结果无论初始拔牙槽配置如何，与 ARP 相比，GBR 均显示出更好的骨形成和更大的骨增益。尽管 ARP 维持了先前存在的牙槽嵴尺寸，但在 8 周的随访中仍然检测到种植体周围骨缺损。组织形态计量学分析证实，与基线相比，GBR 增加了牙槽嵴的尺寸，并且 GBR 的增强和骨再生效果比 ARP 更大。结论 早期植入 ARP 可以减轻狭窄牙槽嵴的牙槽嵴变化。然而，与 ARP 相比，早期种植体植入同时进行 GBR 为增强种植体周围的骨再生和更大的牙槽嵴增高创造了条件，无论拔牙槽配置如何。