BackgroundThis study investigated the effect of a 4‐week free‐sugar avoidance on periodontal parameters during periodontal therapy.MethodsTwenty‐one patients with untreated periodontitis and daily free‐sugar intake were allocated to a sugar avoidance group (SAG) and a control group (CG). The SAG received a 45‐min dietary consultation and was instructed to avoid free sugars during the following 4 weeks after subgingival instrumentation, while the CG continued with their regular diet. Bleeding on probing (BOP), plaque control record, body weight (BW), visceral fat (FATv), and a food frequency questionnaire (FFQ) were collected at baseline (T1), 4 weeks (T2), and 8 weeks (T3) after subgingival instrumentation.ResultsThe main outcome parameter BOP was significantly reduced at T2 by 40.3% ± 15.54 in the SAG and 34% ± 12.47 in the CG (intra‐p value both <0.001, inter‐p value 0.361). A linear regression analysis of changes at patient level adjusted for age and FATv revealed a significant group difference for BOP (regression coefficient = –6.8; p = 0.019). Significant reductions were observed in BW, FATv and mean daily intake of free sugars (–14.4 g/day), and a significant increase of vitamin C derived from fruits (75.89 mg/day) at T2 in the SAG only.ConclusionThis study may indicate additional beneficial effects of a sugar avoidance on periodontal and metabolic parameters, and nutritional intake during periodontal therapy.German Clinical Trials Register (DRKS00026699).Plain Language SummaryThe current widespread free‐sugar consumption is linked to an increasing incidence of chronic non‐communicable diseases. Data indicate a relationship between sugar intake and a higher prevalence of periodontitis and increased gingival inflammation.This study showed that free‐sugar avoidance after periodontal therapy had additional beneficial effects on periodontal and metabolic parameters in 10 test and 11 control patients. After 4 weeks of avoiding free sugars like sweets, processed white flour, juice, and so forth, periodontal bleeding was significantly reduced in both groups (–40.3% test group, –34% control group). Further regression analysis revealed a significant difference between groups favoring the intervention. Additionally, body weight and visceral fat were significantly reduced in the intervention group, only. To avoid sugar, patients were allowed to replace it with whole fruit, which led to increased levels of micronutrients such as vitamin C. Therefore, free‐sugar avoidance may be of therapeutic benefit in addition to periodontal therapy. Further research is needed to investigate this effect in larger cohorts.

中文翻译：

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牙周治疗期间 4 周避免游离糖的影响：一项探索性随机对照临床试验


背景本研究调查了牙周治疗期间 4 周避免游离糖对牙周参数的影响。方法将 21 名未经治疗的牙周炎且每日摄入游离糖的患者分配至避免糖组 (SAG) 和对照组 (CG)。 ）。 SAG 接受了 45 分钟的饮食咨询，并被指示在龈下器械植入后的接下来 4 周内避免摄入游离糖，而 CG 则继续常规饮食。在基线 (T1)、4 周 (T2) 和 8 周 (T3) 时收集探诊出血 (BOP)、斑块控制记录、体重 (BW)、内脏脂肪 (FATv) 和食物频率问卷 (FFQ)结果主要结果参数 BOP 在 T2 时显着降低，SAG 中降低了 40.3% ± 15.54，CG 中降低了 34% ± 12.47（内部 p 值均为 <0.001，间 p 值 0.361）。根据年龄和 FATv 调整的患者水平变化的线性回归分析显示，BOP 存在显着的组间差异（回归系数 = –6.8；p = 0.019）。仅在 SAG 中，在 T2 时观察到 BW、FATv 和平均每日游离糖摄入量（–14.4 克/天）显着减少，而源自水果的维生素 C（75.89 毫克/天）显着增加。结论这项研究可能表明避免糖对牙周和代谢参数以及牙周治疗期间营养摄入的额外有益影响。德国临床试验登记册（DRKS00026699）。通俗语言摘要当前广泛的无糖消费与慢性非传染性疾病发病率的增加有关。数据表明，糖的摄入量与牙周炎和牙龈炎症的患病率较高之间存在关系。这项研究表明，牙周治疗后避免游离糖对 10 名测试患者和 11 名对照患者的牙周和代谢参数有额外的有益影响。避免食用糖果、加工白面粉、果汁等游离糖 4 周后，两组的牙周出血均显着减少（试验组 –40.3%，对照组 –34%）。进一步的回归分析显示，支持干预的群体之间存在显着差异。此外，仅干预组的体重和内脏脂肪显着减少。为了避免吃糖，患者被允许用整个水果代替，这导致维生素 C 等微量营养素的水平增加。因此，除了牙周治疗之外，避免游离糖可能还具有治疗益处。需要进一步的研究来调查更大群体中的这种效应。