BackgroundThe composite outcome measure (COM) more comprehensively assesses the clinical efficacy of regenerative surgery than a single probing measurement. We aimed to assess long‐term success defined by the COM (clinical attachment level [CAL] gain of ≥3 mm and postsurgery probing pocket depth [PPD] ≤ 4 mm) and influencing factors of regenerative surgery using bone substitutes and resorbable collagen membrane (RM) for intra‐bony defects (IBDs).MethodsWe retrospectively collected data from patients who underwent regenerative surgery using deproteinized bovine bone mineral (DBBM) and RM for IBDs. CAL and PPD values were compared at baseline (preoperative), 1 year (short‐term), and at the last follow‐up (5–10 years). Multivariate logistic regressions were performed to identify factors influencing COM‐based long‐term success.ResultsEighty‐one defects in 75 teeth of 33 patients who completed follow‐up (6.5 ± 1.4 years) were included. One tooth was lost. All defects with complete follow‐up exhibited long‐term average CAL gain (3.00 ± 2.00 mm, 95% confidence interval [CI]: 2.56–3.44 mm, p < 0.001) and PPD reduction (2.06 ± 1.91 mm, 95% CI: 1.64–2.49 mm, p < 0.001). Long‐term success was achieved in 38.8% of IBDs. CAL and PPD values were comparable between 1 year and the last follow‐up. Logistic regression analyses revealed that male sex (odds ratio [OR] = 0.23, 95% CI: 0.07–0.75) and bleeding on probing (BOP) during supportive periodontal therapy (OR = 0.96, 95% CI: 0.94–0.99) were risk factors for long‐term success.ConclusionsRegenerative surgery with DBBM and RM for IBDs can achieve some degree of long‐term success defined by COM. However, within this study's limitations, male sex and higher BOP incidence postoperatively are negatively associated with optimal long‐term success.Clinical trial numberChiCTR2300069016.

中文翻译：

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骨内缺损再生手术的长期成功及影响因素：一项回顾性队列研究


背景综合结果测量（COM）比单一探查测量更全面地评估再生手术的临床疗效。我们的目的是评估由 COM 定义的长期成功（临床附着水平 [CAL] 增益≥3 mm 和术后探查袋深度 [PPD] ≤ 4 mm）以及使用骨替代物和可吸收胶原膜的再生手术的影响因素（ RM) 治疗骨内缺陷 (IBD)。方法我们回顾性收集了接受使用去蛋白牛骨矿物质 (DBBM) 和 RM 治疗 IBD 的再生手术的患者的数据。比较基线（术前）、1 年（短期）和最后一次随访（5-10 年）时的 CAL 和 PPD 值。进行多变量逻辑回归以确定影响基于 COM 的长期成功的因素。结果纳入了完成随访（6.5 ± 1.4 年）的 33 名患者的 75 颗牙齿的 81 个缺损。一颗牙齿掉了。完整随访的所有缺陷均表现出长期平均 CAL 增益（3.00 ± 2.00 mm，95% 置信区间 [CI]：2.56–3.44 mm， p < 0.001）和 PPD 降低（2.06 ± 1.91 mm，95% CI：1.64–2.49 mm， p < 0.001）。 38.8% 的 IBD 取得了长期成功。 1 年和最后一次随访期间的 CAL 和 PPD 值具有可比性。 Logistic 回归分析显示，男性（比值比 [OR] = 0.23，95% CI：0.07–0.75）和牙周支持治疗期间探诊出血（BOP）（OR = 0.96，95% CI：0.94–0.99）是风险结论采用 DBBM 和 RM 治疗 IBD 的再生手术可以实现 COM 定义的一定程度的长期成功。 然而，在本研究的局限性内，男性和术后较高的 BOP 发生率与最佳长期成功呈负相关。临床试验编号 ChiCTR2300069016。