BackgroundThis randomized controlled trial with two parallel arms and a 1:1 allocation ratio aimed to compare early microvascular healing (primary outcome), surgical times, and patient‐reported outcomes (PROM) after harvesting palatal epithelialized gingival grafts (EGG), where hemostasis was achieved with sutures and hemostatic sponges (control) or with a sutureless approach (test).MethodsFrom a total of 33 patients, 34 EGG were harvested. Thirty‐two were randomized to the test/control group (n = 16) and two were excluded. Early palatal microvascular healing was assessed at 7, 14, and 30 days with laser speckle contrast imaging (LSCI). Postoperative bleeding, pain, discomfort, and analgesic consumption were assessed over 2 weeks with a dedicated questionnaire.ResultsA faster onset and resolution of postharvest hyperemia was observed in the test group where peak blood flow was reached at 7 days. No significant blood flow differences were observed between the groups at any of the evaluated timepoints. The mean surgical time was 13 min shorter in the test (p = 0.00). No significant differences were observed for postoperative bleeding and analgesic consumption at any timepoint.ConclusionsThe tested approach represents a viable alternative to the standard one, providing no relevant differences in microvascular, clinical, and patient‐related results, but with significantly shorter surgical times.

中文翻译：

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不使用止血缝合线收获上皮牙龈移植物：使用激光散斑对比成像的随机临床试验


背景这项随机对照试验采用两个平行臂和 1:1 分配比例，旨在比较采摘腭上皮化牙龈移植物 (EGG) 后的早期微血管愈合（主要结果）、手术时间和患者报告结果 (PROM)，其中止血是通过缝合和止血海绵（对照）或无缝线方法（测试）实现。方法从总共 33 名患者中采集了 34 个 EGG。 32 人被随机分配到测试组/对照组（ n = 16），其中两个被排除。使用激光散斑对比成像 (LSCI) 在第 7、14 和 30 天评估早期腭微血管愈合情况。通过专门的调查问卷对术后出血、疼痛、不适和镇痛药消耗量进行了 2 周的评估。结果在测试组中观察到采后充血的发生和消退更快，在 7 天时达到峰值血流量。在任何评估的时间点，各组之间均未观察到显着的血流量差异。测试中平均手术时间缩短了 13 分钟（ p = 0.00）。在任何时间点均未观察到术后出血和镇痛药用量存在显着差异。结论所测试的方法是标准方法的一种可行替代方案，在微血管、临床和患者相关结果方面没有相关差异，但手术时间显着缩短。