BackgroundAlthough several studies have demonstrated a bidirectional relationship between nonalcoholic fatty liver disease (NAFLD) and chronic periodontitis, few studies have reported that NAFLD causes chronic periodontitis, especially in the Asian population.MethodsThis study was conducted on 129,087 individuals, and the NAFLD score was assessed using the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and Framingham Steatosis Index (FSI). The incidence of chronic periodontitis was defined as a diagnostic code with dental procedures. Multi‐variable adjusted Cox proportional hazard regression analysis was performed with hazard ratio (HR) and 95% confidence intervals (CIs).ResultsNine thousand one hundred and twenty‐eight chronic periodontitis cases (7.1%) were identified during a mean 7.4 years follow‐up period. Each NAFLD score was related to chronic periodontitis. In the FLI score, HR and 95% CIs for the incidence of chronic periodontitis compared with a low FLI group were as follows: indeterminate FLI: 1.19 (1.12–1.26), high FLI: 1.32 (1.18–1.47). In the HSI and FSI scores, HR and 95% CIs for the incidence of chronic periodontitis were 1.13 (1.05–1.22) and 1.23 (1.05–1.31), respectively.ConclusionsAll NAFLD scores were associated with chronic periodontitis in the Korean population. As chronic periodontitis can aggravate the liver status, patients with NAFLD may need regular dental visits.

中文翻译：

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非酒精性脂肪肝疾病评分与慢性牙周炎之间的关联：一项回顾性队列研究


背景虽然一些研究已经证明非酒精性脂肪性肝病 (NAFLD) 和慢性牙周炎之间存在双向关系，但很少有研究报道 NAFLD 会导致慢性牙周炎，特别是在亚洲人群中。 方法本研究对 129,087 名个体进行，并对 NAFLD 评分进行了评估使用脂肪肝指数 (FLI)、肝脂肪变性指数 (HSI) 和弗雷明汉脂肪变性指数 (FSI)。慢性牙周炎的发病率被定义为牙科手术的诊断代码。采用风险比 (HR) 和 95% 置信区间 (CI) 进行多变量调整 Cox 比例风险回归分析。结果在平均 7.4 年随访期间发现了 9128 例慢性牙周炎病例 (7.1%)。上升期。每个 NAFLD 评分均与慢性牙周炎相关。在FLI评分中，与低FLI组相比，慢性牙周炎发生率的HR和95% CI如下：不确定FLI：1.19（1.12-1.26），高FLI：1.32（1.18-1.47）。在 HSI 和 FSI 评分中，慢性牙周炎发病率的 HR 和 95% CI 分别为 1.13 (1.05–1.22) 和 1.23 (1.05–1.31)。 结论 在韩国人群中，所有 NAFLD 评分均与慢性牙周炎相关。由于慢性牙周炎会加重肝脏状况，NAFLD 患者可能需要定期看牙医。