BackgroundThis study aimed to investigate the relationship between the pan‐immune‐inflammation value (PIV) and periodontitis based on a large national survey.MethodsIn the present cross‐sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.ResultsThe associations between PIV and stage III/IV periodontitis followed a U‐shaped pattern (Pnon‐linearity < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01–1.46), third quartile (OR = 1.34; 95% CI: 1.11–1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25–1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (ORQ4vs2 = 1.72, 95% CI: 1.36–2.18) and individuals with hypertension (ORQ4vs2 = 1.78, 95% CI: 1.38–2.28) with significant interactions (Pinteraction < 0.05).ConclusionsThere is a U‐shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.Plain Language SummaryA U‐shaped association exists between the pan‐immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.

中文翻译：

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泛免疫炎症值与牙周炎之间的 U 形关联：NHANES 2009-2014


背景本研究旨在基于一项大型全国调查来探讨泛免疫炎症值（PIV）与牙周炎之间的关系。方法在本次横断面研究中，数据来自2009年国家健康和营养检查调查（NHANES） –2014 年，共有 10,300 名参与者。牙周炎的分类基于2017年的分类方案。使用公式确定PIV：（中性粒细胞计数×单核细胞计数×血小板计数）/淋巴细胞计数。采用限制三次样条和加权多变量逻辑回归分析来评估 PIV 与牙周炎之间的关联。结果 PIV 与 III/IV 期牙周炎之间的关联遵循 U 形模式（磷非线性< 0.001）。在第一个四分位数（比值比 [OR] = 1.21；95% 置信区间 [CI]：1.01–1.46）和第三个四分位数（OR = 1.34；95%）的参与者中，发生 III/IV 期牙周炎的风险呈增加趋势。与第二个四分位数相比，CI：1.11–1.61）和第四个四分位数（OR = 1.47；95% CI：1.25–1.73）。亚组分析表明 PIV 与男性牙周炎有更强的相关性（或Q4vs2 = 1.72，95% CI：1.36–2.18）和高血压患者（或Q4vs2 = 1.78，95% CI：1.38–2.28），具有显着的交互作用（磷相互作用< 0.05）。结论 PIV 与 III/IV 期牙周炎之间存在 U 形关联，这表明牙周炎的潜在辅助治疗策略。 研究发现，较高的 PIV 值与男性和高血压患者的 III/IV 期牙周炎有更强的相关性。需要进一步的前瞻性试验来证实我们结果的有效性。 通俗易懂的语言总结美国成年人的泛免疫炎症值与牙周炎之间存在 U 形关联，表明维持适度的免疫炎症反应对于牙周健康至关重要。