AimTo assess whether guided bone regeneration (GBR) treatment of peri‐implantitis‐related bony defects could improve healing compared to open flap debridement (OFD) at 36 months.Materials and MethodsIn a multi‐centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), mucosal recession (MREC) and patient‐reported outcomes (PROs) were evaluated at 36 months.ResultsFifty individuals attended a supportive peri‐implant therapy program and completed the 36‐month follow‐up. GBR treatment resulted in an RDF of 2.13 ± 1.26 mm compared to 1.64 ± 1.54 mm following OFD (p = .18). No difference was found in PPD, BOP, SUP, REC or PROs between the groups. Successful treatment (no additional bone loss, PPD ≤ 5 mm, no BOP and no SUP) was achieved in 46.2% in TG and 20% in CG (p = .053). Treatment results obtained at 12 months were generally maintained up to 36 months. No significant changes were noticed between 12 and 36 months.ConclusionsAt 36 months, treatment results obtained at 1 year were sustained following both GBR and OFD in patients attending supportive peri‐implant therapy. GBR resulted in more RDF and higher composite treatment success rate than OFD (ClinicalTrials.gov Identifier [NCT02375750]).

中文翻译：

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重建治疗在种植体周围炎手术治疗中的疗效：一项随机临床试验的 3 年随访


目的 评估与开放皮瓣清创术 （OFD） 相比，种植体周围相关骨缺损的引导骨再生 （GBR） 治疗是否可以改善 36 个月时的愈合。材料和方法在一项多中心、随机临床试验中，32 例接受了 OFD（对照组 [CG]）和 34 例 GBR 治疗（试验组 [TG]）。在 36 个月时评估影像学缺损填充 （RDF） 、探诊袋深度 （PPD）、探诊出血 （BOP） 化脓 （SUP）、粘膜萎缩 （MREC） 和患者报告结果 （PROs）。结果50 人参加了支持性种植体周围治疗计划并完成了 36 个月的随访。GBR 处理导致 RDF 为 2.13 ± 1.26 mm，而 OFD 后为 1.64 ± 1.54 mm （p = .18）。组间 PPD 、 BOP 、 SUP 、 REC 或 PRO 无差异。TG 为 46.2%，CG 为 20% （p = .053），成功治疗 （无额外的骨质流失，PPD ≤ 5 mm，无 BOP 和无 SUP） 。12 个月时获得的治疗结果通常可维持至 36 个月。在 12 至 36 个月之间未观察到显著变化。结论在 36 个月时，接受支持性种植体周围治疗的患者在 GBR 和 OFD 后获得的 1 年治疗结果均持续。GBR 导致比 OFD （ClinicalTrials.gov 标识符 [NCT02375750]） 更多的 RDF 和更高的复合处理成功率。