AimTo investigate the association between periodontitis and oral health–related quality of life (OHRQoL) in adults, and to compare OHRQoL across different severities of the disease.Materials and MethodsSearches were conducted in five electronic databases up to December 2023. Observational studies that provided a clear definition of periodontitis and used validated measures of OHRQoL were included. Meta‐analyses were performed both overall and based on factors that could explain heterogeneity between studies.ResultsSixty studies comprising 14,851 individuals were included in the review. Meta‐analyses showed that periodontitis was associated with impaired OHRQoL: any OHRQoL instruments (n = 33 studies; SMD: 0.75, 95% CI: 0.53–0.93), solely using the OHIP‐14 (n = 26 studies; MD: 5.14, 95% CI: 3.64–6.64), and risk assessment (n = 9 studies; adjusted RR: 1.42, 95% CI: 1.12–1.78). Stages III–IV periodontitis had a greater impact than Stages I–II periodontitis. Subgroup and meta‐regression analyses indicated smaller effect size estimates for individuals with comorbidities.ConclusionsPeriodontitis negatively impacts OHRQoL, with a positive score–response relationship found between periodontitis severity and poorer OHRQoL. However, the magnitude of this association appears to be diminished in individuals with comorbidities.

中文翻译：

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牙周炎和口腔健康相关的生活质量：系统评价和荟萃分析


目的调查成人牙周炎与口腔健康相关生活质量 (OHRQoL) 之间的关联，并比较不同疾病严重程度的 OHRQoL。材料和方法截至 2023 年 12 月在五个电子数据库中进行搜索。观察性研究提供了包括牙周炎的明确定义和使用的经过验证的 OHRQoL 测量方法。荟萃分析是整体进行的，并基于可以解释研究之间异质性的因素。结果 包括 14,851 名个体的 60 项研究纳入了该评价。荟萃分析显示，牙周炎与 OHRQoL 受损相关：任何 OHRQoL 工具（n = 33 项研究；SMD：0.75，95% CI：0.53–0.93），仅使用 OHIP-14（n = 26 项研究；MD：5.14， 95% CI：3.64–6.64）和风险评估（n = 9 项研究；调整后 RR：1.42，95% CI：1.12–1.78）。 III-IV期牙周炎比I-II期牙周炎的影响更大。亚组和荟萃回归分析表明，患有合并症的个体的效应大小估计值较小。 结论 牙周炎对 OHRQoL 产生负面影响，牙周炎严重程度与较差的 OHRQoL 之间存在正向评分-反应关系。然而，在患有合并症的个体中，这种关联的程度似乎有所减弱。