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Periodontitis Is Associated With Arterial Stiffness as Measured by Serial Cardio‐Ankle Vascular Index (CAVI): A 10‐Year Cohort Study
Journal of Clinical Periodontology ( IF 5.8 ) Pub Date : 2024-11-07 , DOI: 10.1111/jcpe.14086
Bantita Kanpittaya, Attawood Lertpimonchai, Sanutm Mongkornkarn, Lakshman Samaranayake, Nisakorn Thongmung, Thosaphol Limpijankit, Orawan Charatkulangkun

AimTo investigate the effect of periodontitis on the long‐term changes of the cardio‐ankle vascular index (CAVI).Materials and MethodsA 10‐year retrospective cohort study of 3842 Thai participants (range 25–76 years) with normal CAVI at the study initiation was undertaken. Full‐mouth periodontal examination was performed by calibrated periodontists, and the extent and severity of periodontitis were determined at 5‐year intervals. Serial CAVI measurements were used to examine the incidence of high CAVI (≥ 9.0) and changes in CAVI over time (ΔCAVI).ResultsParticipants with a higher extent or severity of periodontitis were found to have a significantly higher mean ΔCAVI. The incidence of high CAVI was also observed to be higher in those with periodontitis compared to those without it. The adjusted risk ratios for developing high CAVI were 1.309 and 1.513 for localized and generalized periodontitis, respectively. Participants with severe periodontitis had a 37% higher likelihood of developing CAVI ≥ 9.0 compared to individuals with no/mild periodontitis. This risk was consistent with a significant change in ΔCAVI of 0.054–0.140.ConclusionsPeriodontitis, both in terms of extent and severity, was found to have a significant dose‐dependent effect on the risk of developing high CAVI over a 10‐year period, suggesting a causal relationship between these two parameters.

中文翻译:


牙周炎与通过连续心踝血管指数 (CAVI) 测量的动脉僵硬相关:一项为期 10 年的队列研究



目的探讨牙周炎对心踝血管指数 (CAVI) 长期变化的影响。材料和方法对 3842 名泰国参与者 (范围 25-76) 进行了为期 10 年的回顾性队列研究,研究开始时 CAVI 正常。由校准的牙周病医生进行全口牙周检查,每隔 5 年确定一次牙周炎的范围和严重程度。连续 CAVI 测量用于检查高 CAVI (≥ 9.0) 的发生率和 CAVI 随时间的变化 (ΔCAVI)。结果发现牙周炎程度或严重程度较高的参与者的平均 ΔCAVI 显着升高。与没有牙周炎的患者相比,还观察到牙周炎患者高 CAVI 的发生率更高。局部和全身性牙周炎发生高 CAVI 的调整后风险比分别为 1.309 和 1.513。与无/轻度牙周炎患者相比,患有严重牙周炎的参与者发生 CAVI 的可能性高 37% ≥ 9.0。结论牙周炎,在程度和严重程度方面,对 10 年期间发生高 CAVI 的风险具有显着的剂量依赖性影响,表明这两个参数之间存在因果关系。
更新日期:2024-11-07
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