BACKGROUND AND AIM The study 'Periodontitis and Its Relation to Coronary Artery Disease' (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD-compared to periodontally healthy individuals-are at increased risk for cardiovascular (CV) events and death. METHODS A total of 1587 participants (age <75 years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (≥80% alveolar bone height), mild/moderate (79%-66%) or severe (<66%). A composite CV event (first of all-cause death, non-fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow-up period of 9.9 years (range 0.2-12.5 years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan-Meier method and Cox regression. RESULTS The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%; p < 0.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] = 1.26; 95% CI: 1.01-1.57; p = 0.038), following adjustment for age, smoking and diabetes. CONCLUSION The PAROKRANK follow-up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.

中文翻译：

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牙周炎会增加未来心血管事件的风险吗？ PAROKRANK 研究的长期随访。


背景和目的 “牙周炎及其与冠状动脉疾病的关系”(PAROKRANK) 研究报告了牙周炎 (PD) 与首次心肌梗死 (MI) 之间的关联。这项后续研究旨在检验以下假设：与牙周健康个体相比，PD 患者发生心血管 (CV) 事件和死亡的风险更高。方法 2010 年至 2014 年间，共有 1587 名参与者（年龄 <75 岁；女性 19%）进行了牙科检查，包括全景 X 线照片。 PD 分为健康（≥80% 牙槽骨高度）、轻度/中度（79%-66 %) 或严重 (<66%)。在平均 9.9 年（范围 0.2-12.5 年）的随访期内对复合心血管事件（首先是全因死亡、非致命性心梗或中风以及心力衰竭后住院）进行了调查。参与者被分为两组：患有帕金森病和不患有帕金森病的人。使用 Kaplan-Meier 方法和 Cox 回归计算主要事件发生率，按基线牙周状态分层。结果 985 名牙周健康参与者中的事件数量为 187 起（19%），602 名牙周病参与者中的事件数量为 174 起（29%；p < 0.0001）。在对年龄、吸烟和糖尿病进行调整后，PD 患者未来发生事件的可能性较高（风险比 [HR] = 1.26；95% CI：1.01-1.57；p = 0.038）。结论 PAROKRANK 随访显示，帕金森病参与者中心血管事件更为常见，这支持了帕金森病与心血管疾病之间可能存在直接关系的假设。