AimTo investigate whether oral microbiome diversity is associated with all‐cause mortality in the general US population and in individuals with chronic diseases.Materials and MethodsWe included 8224 individuals with oral microbiome diversity data from the National Health and Nutrition Examination Survey (2009–2012), representing 164,000,205 US adults, using a survey‐weighted analysis method. Cox regression analyses were performed to identify the association between oral microbiome diversity and all‐cause mortality.ResultsDuring a survey‐weighted mean follow‐up period of 8.86 years, 429 all‐cause deaths (survey‐weighted number: 7,124,920) occurred in 8224 participants. Cox regression analysis revealed that higher oral microbiome diversity was significantly associated with a lower all‐cause mortality risk. Significant differences in all‐cause mortality risk were observed among the different clusters based on oral microbiome β‐diversity (log‐rank p < 0.001). Subgroup analyses revealed that the oral microbiome diversity was independently associated with all‐cause mortality in individuals with diabetes mellitus and hypertension. A multivariate logistic regression model showed that current smoking and antibiotic use were significantly associated with lower oral microbiome α diversity.ConclusionsHigher oral microbiome diversity was significantly associated with a lower all‐cause mortality risk in the general US population and in individuals with diabetes mellitus and hypertension.

中文翻译：

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美国普通人群和慢性病患者口腔微生物组多样性与全因死亡率的关联：一项前瞻性队列研究


目的调查口腔微生物组多样性是否与美国普通人群和慢性病患者的全因死亡率相关。材料和方法我们使用调查加权分析方法纳入了 8224 名具有全国健康和营养检查调查 （2009-2012） 的口腔微生物组多样性数据的个体，代表 164,000,205 名美国成年人。进行 Cox 回归分析以确定口腔微生物组多样性与全因死亡率之间的关联。结果在 8.86 年的调查加权平均随访期内，8224 名参与者发生了 429 例全因死亡（调查加权数字：7,124,920）。Cox 回归分析显示，较高的口腔微生物组多样性与较低的全因死亡风险显著相关。基于口腔微生物组β多样性，在不同集群中观察到全因死亡风险的显着差异 （log-rank p < 0.001）。亚组分析显示，口腔微生物组多样性与糖尿病和高血压患者的全因死亡率独立相关。多变量 logistic 回归模型显示，当前吸烟和抗生素使用与较低的口腔微生物组α多样性显著相关。结论较高的口腔微生物组多样性与美国普通人群以及糖尿病和高血压个体的较低全因死亡风险显著相关。