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Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment
Journal of Clinical Periodontology ( IF 5.8 ) Pub Date : 2024-08-06 , DOI: 10.1111/jcpe.14048
Flavia R F Teles 1, 2 , Ganesh Chandrasekaran 3 , Lynn Martin 1 , Michele Patel 4 , Michael J Kallan 5 , Camila Furquim 1, 6 , Tahir Hamza 7 , Andrew J Cucchiara 5 , Alpdogan Kantarci 4, 8 , Olivia Urquhart 9, 10 , James Sugai 8, 11 , William V Giannobile 8
Affiliation  

AimTo identify serum‐ and salivary‐derived inflammatory biomarkers of periodontitis progression and determine their response to non‐surgical treatment.Materials and MethodsPeriodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi‐monthly for 1 year without therapy. Periodontitis patients were re‐examined 6 months after non‐surgical periodontal therapy (NSPT). Participants were classified according to disease progression: P0 (no sites progressed; P1: 1–2 sites progressed; P2: 3 or more sites progressed). Ten salivary and five serum biomarkers were measured using Luminex. Log‐transformed levels were compared over time according to baseline diagnosis, progression trajectory and after NSPT. Significant differences were sought using linear mixed models.ResultsP2 presented higher levels (p < .05) of salivary IFNγ, IL‐6, VEGF, IL‐1β, MMP‐8, IL‐10 and OPG over time. Serum analytes were not associated with progression. NSPT led to clinical improvement and significant reduction of IFNγ, IL‐6, IL‐8, IL‐1β, MMP‐8, IL‐10, OPG and MMP‐9 in saliva and of CRP, MMP‐8, MMP‐9 and MPO in serum.ConclusionsPeriodontitis progression results from a sustained pro‐inflammatory milieu that is reflected in salivary biomarkers, but less so in serum, likely because of the limited amount of progression per patient. NSPT can significantly decrease the levels of several salivary analytes.

中文翻译:


牙周炎进展期间和治疗后的唾液和血清炎症生物标志物



目的 识别牙周炎进展的血清和唾液来源的炎症生物标志物,并确定其对非手术治疗的反应。 材料和方法 每两个月对牙周健康患者 (H; n = 113) 和牙周炎患者 (P; n = 302) 进行监测1年未治疗。牙周炎患者在非手术牙周治疗(NSPT)后 6 个月进行重新检查。根据疾病进展对参与者进行分类:P0(无部位进展;P1:1-2 个部位进展;P2:3 个或更多部位进展)。使用 Luminex 测量了 10 种唾液生物标志物和 5 种血清生物标志物。根据基线诊断、进展轨迹和 NSPT 后,对一段时间内的对数转换水平进行比较。使用线性混合模型寻找显着差异。结果随着时间的推移,P2 唾液中 IFNγ、IL-6、VEGF、IL-1β、MMP-8、IL-10 和 OPG 的水平较高 (p < .05)。血清分析物与进展无关。 NSPT 导致临床改善,唾液中的 IFNγ、IL-6、IL-8、IL-1β、MMP-8、IL-10、OPG 和 MMP-9 以及 CRP、MMP-8、MMP-9 和 CRP 显着降低。血清中的 MPO。 结论 牙周炎的进展是由唾液生物标志物中反映的持续促炎环境引起的,但在血清中的情况较少,可能是因为每个患者的进展量有限。 NSPT 可以显着降低几种唾液分析物的水平。
更新日期:2024-08-06
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