AimTo investigate the effect of a 16‐week whole‐food plant‐based diet (WPBD) on periodontal parameters in patients with increased cardiometabolic risk.Materials and MethodsA total of 36 participants from a randomized clinical trial received additional periodontal assessment. The intervention group (n = 17) followed a WPBD for 16 weeks, whereas the control group (CG) (n = 19) was instructed not to change their diet. Measurements were assessed at baseline (t1), week 8 (t2) and week 16 (t3). Periodontal examination included bleeding on probing (BOP), periodontal inflamed surface area (PISA) and plaque index (PI) on six index teeth, salivary pH and matrix‐matalloproteinase‐8 (MMP‐8).ResultsAt t3, the mean PISA of the index teeth was reduced by 32 mm2 (53.8) in the WPBD group and increased by 22.6 mm2 (45.1) in the CG group (intra‐group p = 0.255 and p = 0.977, respectively), BOP changes were similar (intra‐group p = 0.89 and p = 0.839, respectively). MMP‐8 values reduced in the WPBD group by 50.73 ng/mL (117) and in the CG by 5.40 ng/mL (96.6) (intra‐group p = 0.066, p = 0.837, respectively). Difference in change (t3 − t1) between the groups was p = 0.001, p = 0.003 and p = 0.032, respectively. Saliva pH increased in the WPBD group only (intra‐group p = 0.007).ConclusionA trend towards stabilization of the inflammatory parameters (BOP, PISA) was observed in the WPBD group. Because of the non‐significant changes within the groups, this study highlights the imperative for future studies.ClinicalTrials.gov identifierNCT03901183.

中文翻译：

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全食植物性饮食对心血管危险因素患者牙周参数的影响：一项随机临床试验的二次亚组分析


目的研究 16 周全食物植物性饮食 （WPBD） 对心脏代谢风险增加患者牙周参数的影响。材料和方法来自随机临床试验的共有 36 名参与者接受了额外的牙周评估。干预组 （n = 17） 跟踪 WPBD 16 周，而对照组 （CG） （n = 19） 被指示不要改变饮食。在基线 （t1） 、第 8 周 （t2） 和第 16 周 （t3） 评估测量结果。牙周检查包括探诊出血 （BOP）、牙周发炎表面积 （PISA） 和 6 颗食牙牙的牙菌斑指数 （PI）、唾液 pH 值和基质-马塔洛蛋白酶-8 （MMP-8）。结果在 t3 时，WPBD 组食粮齿的平均 PISA 减少了 32 mm2 （53.8），CG 组增加了 22.6 mm2 （45.1） （组内 p = 0.255 和 p = 0.977），BOP 变化相似 （组内 p = 0.89 和 p = 0.839，分别为）。WPBD 组的 MMP-8 值降低了 50.73 ng/mL （117），CG 组的 MMP-8 值降低了 5.40 ng/mL （96.6） （组内 p = 0.066，p = 0.837）。两组之间的变化差异 （t3 − t1） 分别为 p = 0.001、p = 0.003 和 p = 0.032。仅在 WPBD 组中唾液 pH 值升高 （组内 p = 0.007）。结论WPBD 组观察到炎症参数 （BOP、PISA） 趋于稳定。由于组内的变化不显著，本研究强调了未来 studies.ClinicalTrials.gov 标识符NCT03901183的必要性。