Background/aims This study aimed to investigate the clinical characteristics and treatment outcomes of patients with active central serous chorioretinopathy (CSC) and foveal atrophy. Methods Patients diagnosed with active idiopathic CSC using multimodal imaging and followed up for at least 6 months were included. They were divided into two groups (foveal atrophy group vs foveal non-atrophy group) according to a cut-off central foveal thickness of 120 µm on baseline optical coherence tomography (OCT). Baseline characteristics, angiographic and tomographic features and treatment outcomes were compared between the two groups. Results Of the 463 patients, 92 eyes of 92 patients (19.9%) were in the foveal atrophy group and 371 eyes of 371 patients (80.1%) were in the foveal non-atrophy group. The baseline subretinal fluid (SRF) height was 111.3±76.8 µm in the foveal atrophy group and 205.0±104.4 µm in the foveal non-atrophy group on OCT images (p<0.001). Complete resolution of SRF after treatment was noted in 60.4% and 93.5% of patients in the foveal atrophy and foveal non-atrophy groups at the final visit, respectively (p<0.001). The foveal atrophy group showed worse visual acuity at baseline (logarithm of the minimum angle of resolution, 0.43±0.33 vs 0.13±0.18, p<0.001) and final visit (0.41±0.32 vs 0.05±0.15, p=0.035). Conclusions CSC with foveal atrophy was associated with a shallow SRF height, low treatment efficacy and poor vision before and after treatment. We suggest that early active treatment should be considered for eyes with CSC accompanied by a persistent shallow SRF and foveal atrophy. Data sharing not applicable as no datasets generated and/or analysed for this study.

中文翻译：

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活动性中心性浆液性脉络膜视网膜病变患者首次就诊时中心凹萎缩：特征和治疗结果


背景/目的 本研究旨在探讨活动性中枢性浆液性脉络膜视网膜病变 （CSC） 和中心凹萎缩患者的临床特征和治疗结果。方法 纳入使用多模态成像诊断为活动性特发性 CSC 并随访至少 6 个月的患者。根据基线光学相干断层扫描 （OCT） 上 120 μm 的截留中央中心凹厚度，将他们分为两组 （中心凹萎缩组 vs 中心凹非萎缩组）。比较两组之间的基线特征、血管造影和断层扫描特征以及治疗结局。结果 463 例患者中，92 例患者中 92 只眼 （19.9%） 为中心凹萎缩组，371 例患者中 371 只眼 （80.1%） 为中心凹非萎缩组。OCT 图像上基线视网膜下液 （SRF） 高度±中心凹萎缩组为 111.376.8 μm，中心凹非萎缩组为 205.0±104.4 μm（p<0.001）。在最后一次就诊时，中心凹萎缩组和中心凹非萎缩组分别有 60.4% 和 93.5% 的患者在治疗后 SRF 完全消退 （p<0.001）。中心凹萎缩组在基线 （最小分辨率角的对数，0.43±0.33 vs 0.13±0.18，p<0.001） 和最终就诊 （0.41±0.32 vs 0.05±0.15，p=0.035） 的视力较差。结论 CSC 伴中心凹萎缩与治疗前后 SRF 高度浅、治疗效果低、视力差相关。我们建议对于伴有持续性浅层 SRF 和中心凹萎缩的 CSC 眼，应考虑早期积极治疗。数据共享不适用，因为没有为本研究生成和/或分析数据集。