Role of lens in early refractive development: evidence from a large cohort of Chinese children,British Journal of Ophthalmology

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Role of lens in early refractive development: evidence from a large cohort of Chinese children
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-12-01 , DOI: 10.1136/bjo-2023-324882
Xiaotong Han ₁ , Ruilin Xiong ₁ , Ling Jin ₁ , Shuai Chang ₁ , Qianyun Chen ₁ , Decai Wang ₁ , Xiang Chen ₁ , Yabin Qu ₂ , Weijia Liu ₃ , Mingguang He _{1,

4} , Ian Morgan ₅ , Yangfa Zeng ₆ , Yizhi Liu ₁

Affiliation

Aims To document longitudinal changes in spherical equivalent refraction (SER) and related biometric factors during early refractive development. Methods This was a prospective cohort study of Chinese children, starting in 2018 with annual follow-ups. At each visit, children received cycloplegic autorefraction and ocular biometry measurements. Lens power (LP) was calculated using Bennett’s formula. Children were divided into eight groups based on baseline age: the 3-year-old (n=426, 49.77% girls), 4-year-old (n=834, 47.36% girls), 6-year-old (n=292, 46.58% girls), 7-year-old (n=964, 43.46% girls), 9-year-old (n=981, 46.18% girls), 10-year-old (n=1181, 46.32% girls), 12-year-old (n=504, 49.01%) and 13-year-old (n=644, 42.70%) age groups. Results This study included right-eye data from 5826 children. The 3-year-old and 4-year-old age groups demonstrated an inflection point in longitudinal SER changes at a mild hyperopic baseline SER (+1 to +2 D), with children with more myopic SER showing hyperopic refractive shifts while those with more hyperopic SER showing myopic shifts. The hyperopic shift in SER was mainly attributed to rapid LP loss and was rarely seen in the older age groups. Axial elongation accelerated in the premyopia stage, accompanied by a partially counter-balancing acceleration of LP loss. For children aged 3–7 years, those with annual SER changes <0.25 D were all mildly hyperopic at baseline (mean: 1.23 D, 95% CI 1.20 to 1.27 D). Conclusion Our findings suggest that during early refractive development, refractions cluster around or above +1.00 D. There is a pushback process in which increases in the rate of LP occur in parallel with increases in axial elongation. Data are available on reasonable request. Data will be shared on reasonable request to pursue additional studies or for replication.

更新日期：2024-11-22

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