Background/aims The aims of this study is to evaluate the anatomic, visual outcomes and associated prognostic factors in patients with advanced retinopathy of prematurity (ROP) following vitrectomy. Methods A retrospective cohort study of patients with ROP who underwent vitrectomy from 2005 to 2016 was conducted. All the patients had a follow-up period of at least 5 years. Univariate and multivariable logistic regression analyses were used to explore the factors related to unfavourable outcomes. Results In total, 81 eyes of 51 patients were included. The mean age at last follow-up was 10.2 years. The anatomic success rate was 96.3% (26/27) for stage 4A, 90.9% (20/22) for stage 4B and 31.3% (10/32) for stage 5 ROP (p<0.01). The mean logMAR best corrected visual acuity of the stage-4A eyes was the highest, followed by those of stage-4B and stage-5 eyes (0.8, 1.5 and 2.6 for stages 4A, 4B and 5, respectively; p<0.01). High myopia (≤ −5.0 D) was noted in 70.8% and 71.4% of stage-4A and stage-4B eyes, respectively. Cataract was the most common complication (25.9%), followed by corneal opacity (17.3%), strabismus (16.1%), and phthisis (16.1%). Stage of the disease was a poor prognostic factor in all vitrectomised eyes (p<0.01). Vitrectomy combined lensectomy was a significant predictor for poor anatomic outcomes for stage-4 eyes (p=0.03). Presence of plus disease was also a possible factor affecting the surgical outcomes. Conclusion The long-term surgical outcomes of the eyes with stage 4A and 4B ROP were favourable. Management of stage 5 ROP remained challenging. Data are available upon reasonable request.

中文翻译：

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玻璃体切除术后晚期早产儿视网膜病变的远期手术结局及预后因素分析


背景/目的 本研究的目的是评估玻璃体切除术后晚期早产儿视网膜病变 （ROP） 患者的解剖学、视觉结果和相关预后因素。方法 对 2005 年至 2016 年接受玻璃体切除术的 ROP 患者进行回顾性队列研究。所有患者的随访期至少为 5 年。采用单变量和多变量 logistic 回归分析探讨与不良结局相关的因素。结果 共纳入 51 例患者的 81 只眼。最后一次随访的平均年龄为 10.2 岁。4A 期解剖学成功率为 96.3% （26/27），4B 期为 90.9% （20/22），5 期 ROP 为 31.3% （10/32） （p<0.01）。4A 期眼的平均 logMAR 最佳矫正视力最高，其次是 4B 期和 5 期眼 （4A 期、 4B 期和 5 期分别为 0.8、1.5 和 2.6;p<0.01）。高度近视 （≤ -5.0 D） 分别见于 70.8% 和 71.4% 的 4A 期和 4B 期眼。白内障是最常见的并发症 （25.9%），其次是角膜混浊 （17.3%）、斜视 （16.1%） 和肺结核 （16.1%）。疾病分期是所有玻璃体切除术眼的不良预后因素 （p<0.01）。玻璃体切除术联合晶状体切除术是 4 期眼解剖结果不良的重要预测因子 （p=0.03）。plus 疾病的存在也是影响手术结局的一个可能因素。结论 4A 期和 4B 期 ROP 眼的远期手术结局良好。第 5 阶段 ROP 的管理仍然具有挑战性。数据可根据合理要求提供。