Background/aims Handheld swept-source optical coherence tomography (SS-OCT) was previously used to measure foveal maturity through semiautomated methods in awake premature infants. This study assesses the relationship between foveal maturity and retinopathy of prematurity (ROP) severity. Methods This is a prospective, observational study using handheld SS-OCT imaging of premature infants undergoing ROP screening. A semiautomated segmentation algorithm measured foveal angle, total retinal cross-sectional area, and retinal and choroid thicknesses at the fovea and parafovea, excluding significant macular oedema. Measures were correlated with ROP severity using a mixed model approach. Results 99 eye imaging sessions from 26 preterm infants were included. Average birth weight was 1057.6±324.8 g. Gestational age and postmenstrual age at imaging were 29.1±3.0 and 36.1±3.8 weeks, respectively. Stage 3 ROP occurred in 16/99 (16.2%) exams. Shallow foveal angle and higher inner retinal fovea/parafoveal (F/P) ratio correlated with more posterior ROP zone (zone 2: 119.2°±20.9° vs zone 3: 96.5°±16.7° and zone 2: 0.6±0.2 vs zone 3: 0.4±0.1, respectively, both p<0.001). Inner retinal F/P ratio was greater in eyes with higher ROP stage (stage 3: 0.6±0.2 vs stage 0 or mature: 0.4±0.2, p=0.03) but this relationship was not seen for outer retina (p=0.29). Larger retinal cross-sectional area coincided with worse ROP stage (stage 3: 1.9±0.06 mm2 vs stage 0 or mature: 1.6±0.04 mm2, p<0.001) and zone (zone 2: 1.6±0.04 mm2 vs zone 3: 1.7±0.04 mm2, p=0.01). Conclusions SS-OCT semiautomated measurements of inner retinal F/P ratio, foveal angle and retinal cross-sectional area may serve as ROP severity biomarkers. Data are available on reasonable request.

中文翻译：

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手持式扫描源光学相干断层扫描对中心凹不成熟的半自动测量与早产儿严重程度的视网膜病变相关


背景/目的 手持式扫描源光学相干断层扫描 （SS-OCT） 以前用于通过半自动方法测量清醒早产儿的中心凹成熟度。本研究评估了中心凹成熟与早产儿视网膜病变 （ROP） 严重程度之间的关系。方法 这是一项使用手持式 SS-OCT 成像对接受 ROP 筛查的早产儿进行的前瞻性观察性研究。半自动分割算法测量中央凹角、视网膜总横截面积以及中央凹和旁中央凹的视网膜和脉络膜厚度，不包括明显的黄斑水肿。使用混合模型方法将测量值与 ROP 严重程度相关联。结果 共纳入 26 例早产儿的 99 次眼部影像学检查。平均出生体重为 1057.6±324.8 克。影像学检查的胎龄和胎龄分别为 29.1±3.0 和 36.1±3.8 周。第 3 阶段 ROP 发生在 16/99 （16.2%） 的考试中。浅中央凹角和较高的视网膜内中央凹/中心凹旁 （F/P） 比率与更多的后 ROP 区相关 （2 区：119.2°±20.9° vs 3 区：96.5°±16.7° 和 2 区：0.6±0.2 vs 3 区：0.4±0.1，均为 p<0.001）。ROP 阶段较高的眼睛 （3 期：0.6±0.2 vs 0 期或成熟期：0.4±0.2，p=0.03） 的视网膜内 F/P 比值更高，但在外视网膜上未观察到这种关系 （p=0.29）。较大的视网膜横截面积与较差的 ROP 阶段 （3 期：1.9±0.06 mm2 vs 0 期或成熟期：1.6±0.04 mm2，p<0.001）和区域 （2 区：1.6±0.04 mm2 vs 3 区：1.7±0.04 mm2，p=0.01）。结论 视网膜内 F/P 比值、中心凹角和视网膜横截面积的 SS-OCT 半自动测量可作为 ROP 严重程度生物标志物。数据可应合理要求提供。