Background/aims To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD OCT) combined with OCT angiography (OCTA) for myopic myopic macular neovascularisation (MNV) activity. Methods Both eyes of patients with myopic MNV diagnosed with fluorescein angiography (FA), SD OCT and OCTA were assessed by unmasked investigators. The images were deidentified and randomised before graded by masked investigators, who determined the presence of active myopic MNV by using SD OCT together with OCTA without FA and by FA alone, respectively. The findings of masked investigators were compared with unmasked investigators. Results 213 eyes of 110 patients comprising 499 imaging episodes were eligible for grading. For diagnosing new-onset myopic MNV without FA, combined use of SD OCT and OCTA had a sensitivity of 0.94, specificity of 0.84 and area under the curve (AUC) of 0.92. FA had a sensitivity of 0.52 (p<0.01), specificity of 0.80 (p=0.38) and AUC of 0.66 (p<0.01). For recurrent myopic MNV, the combination of SD OCT and OCTA had a sensitivity of 0.98, specificity of 0.78 and AUC of 0.88. FA had a sensitivity of 0.50 (p=0.04), specificity of 0.76 (p=0.85) and AUC of 0.63 (p=0.01). Myopic traction maculopathy was more frequently associated with recurrent myopic MNV (p<0.01). Conclusion SD OCT with dense volumetric scan was highly sensitive for diagnosing myopic MNV. The addition of OCTA improved the diagnostic specificity without FA. Monitoring of the longitudinal changes on SD OCT and judicious use of FA is a reliable surveillance strategy for myopic MNV. Data are available on reasonable request. The data that support the findings of this study are available from the corresponding author, DS-CN, on reasonable request.

中文翻译：

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提高光谱域光学相干断层扫描和光学相干断层扫描血管造影的准确性，以监测近视性黄斑新生血管活动


背景/目的 评价光谱域光学相干断层扫描 （SD OCT） 联合 OCT 血管造影 （OCTA） 对近视性黄斑新生血管形成 （MNV） 活动的诊断准确性。方法 由未戴口罩的研究者评估荧光素血管造影 （FA） 、SD OCT 和 OCTA 诊断的近视 MNV 患者的双眼。在由蒙面研究人员进行分级之前，对图像进行了去标识化和随机化，他们分别通过使用 SD OCT 与无 FA 的 OCTA 和单独使用 FA 来确定活动性近视 MNV 的存在。将蒙面调查员的研究结果与未蒙面调查员的结果进行了比较。结果 110 例患者的 213 只眼，包括 499 次影像学检查事件，符合分级条件。对于诊断无 FA 的新发近视 MNV，SD OCT 和 OCTA 联合使用的敏感性为 0.94，特异性为 0.84，曲线下面积 （AUC） 为 0.92。FA 的敏感性为 0.52 （p<0.01），特异性为 0.80 （p=0.38），AUC 为 0.66 （p<0.01）。对于复发性近视 MNV，SD OCT 和 OCTA 联合使用的敏感性为 0.98，特异性为 0.78，AUC 为 0.88。FA 的敏感性为 0.50 （p=0.04），特异性为 0.76 （p=0.85），AUC 为 0.63 （p=0.01）。近视牵引性黄斑病变更常与复发性近视 MNV 相关 （p<0.01）。结论 SD OCT 联合密集体积扫描对诊断近视 MNV 高度敏感。添加 OCTA 提高了无 FA 的诊断特异性。监测 SD OCT 的纵向变化和明智使用 FA 是近视 MNV 的可靠监测策略。数据可应合理要求提供。支持本研究结果的数据可应合理要求从通讯作者 DS-CN 处获得。