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Number of macula optical coherence tomography scans needed to detect glaucoma progression
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-12-11 , DOI: 10.1136/bjo-2023-324916
Golnoush Mahmoudinezhad, Sasan Moghimi, Kareem Latif, Nicole Brye, Evan Walker, Takashi Nishida, Kelvin H Du, Gopikasree Gunasegaran, Jo-Hsuan Wu, Jeffrey M Liebmann, Massimo A Fazio, Christopher A Girkin, Linda M Zangwill, Robert N Weinreb

Background To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT). Materials and methods From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years. Patients with 4 or more OCT tests were selected to calculate the longitudinal rates of GCC thickness change over time by linear regression. A computer simulation was then used to generate real-world GCC data and assess the time required to detect progression at different loss rates and testing frequencies based on variability estimates. Time and accuracy to detect worsening of progression were calculated. Results As testing frequency increased, the time required to detect a statistically significant negative GCC slope decreased, but not proportionally. All eyes with a GCC loss of −1 µm/year progressed after 3.8, 2.6 and 2.2 years on average when testing was conducted one, two and three times per year, respectively. For eyes with a GCC loss of −1.5 µm/year, progression was identified after 3.3, 2.2, and 1.8 years on average, respectively. Conclusion Increasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year. However, two times per year testing may be sufficient in clinical settings to detect progression and also to reduce the healthcare burden. Trial registration numbers [NCT00221897][1], [NCT00221923][2]. Data are available upon reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00221897&atom=%2Fbjophthalmol%2Fearly%2F2024%2F12%2F11%2Fbjo-2023-324916.atom [2]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00221923&atom=%2Fbjophthalmol%2Fearly%2F2024%2F12%2F11%2Fbjo-2023-324916.atom

中文翻译:


检测青光眼进展所需的黄斑光学相干断层扫描次数



背景 评估检测频率对光学相干断层扫描 (OCT) 检测神经节细胞复合体 (GCC) 具有统计学意义的青光眼进展所需时间的影响。材料和方法 从多中心青光眼登记处,平均 4.4 年招募了 201 名青光眼患者的 332 只眼睛。选择进行 4 次或更多次 OCT 测试的患者,通过线性回归计算 GCC 厚度随时间变化的纵向速率。然后使用计算机模拟生成真实世界的 GCC 数据,并根据可变性估计评估在不同损失率和测试频率下检测进展所需的时间。计算检测进展恶化的时间和准确性。结果 随着检测频率的增加,检测具有统计学意义的负 GCC 斜率所需的时间减少,但不成比例地减少。当分别每年进行 1 次、2 次和 3 次测试时,所有 GCC 损失为 -1 μm/年的眼睛平均在 3.8 年、2.6 年和 2.2 年后进展。对于 GCC 损失为 -1.5 μm/年的眼睛,平均分别在 3.3 年、 2.2 年和 1.8 年后发现进展。结论 与每年 2 次相比,将黄斑 OCT 检测频率增加到每年 3 次对检测进展的灵敏度更高。然而,在临床环境中,每年两次检测可能足以检测进展并减轻医疗保健负担。试验注册号 [NCT00221897][1], [NCT00221923][2]。数据可根据合理要求提供。[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00221897&atom=%2Fbjophthalmol%2Fearly%2F2024%2F12%2F11%2Fbjo-2023-324916.atom [2]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00221923&atom=%2Fbjophthalmol%2Fearly%2F2024%2F12%2F11%2Fbjo-2023-324916.原子
更新日期:2024-12-12
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