Purpose The purpose is to investigate the association between handgrip strength (HGS) and the risk of future diabetic complications in multicountry cohorts. Methods The association between HGS and diabetic complications was evaluated using cox models among 84 453 patients with pre-diabetes and diabetes from the UK Biobank with a 12-year follow-up. The association between HGS and longitudinal microcirculatory damage rates was assessed among 819 patients with diabetes from the Guangzhou Diabetic Eye Study (GDES) with a 3-year follow-up. Participants were divided into three age groups (<56, 56–65 and ≥65 years), and each group was further subdivided into three HGS tertiles. Results A 5 kg reduction in HGS was associated with increased risk for all-cause mortality (women, HR=1.10, 95% CI: 1.05 to 1.14; p<0.001; men, HR=1.13, 95% CI: 1.11 to 1.15; p<0.001). Women and men in the lowest HGS group exhibited 1.6-times and 1.3–1.5-times higher risk of myocardial infarction and stroke compared with the highest HGS group. In men, there was a higher risk of developing end-stage renal disease (HR=1.83, 95% CI: 1.30 to 2.57; p=0.001), while this was not observed in women. Both sexes in the lowest HGS group had a 1.3-times higher risk of diabetic retinopathy compared with the highest HGS group. In the GDES group, individuals with the lowest HGS showed accelerated microcirculatory damage in retina (all p<0.05). Conclusions Reduced HGS is significantly associated with a higher risk of diabetic complications and accelerated microvascular damage. HGS could serve as a practical indicator of vascular health in patients with pre-diabetes and diabetes. No data are available.

中文翻译：

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握力和糖尿病血管并发症的风险：来自广州糖尿病眼研究和英国队列的证据


目的 目的是调查多国队列中握力 （HGS） 与未来糖尿病并发症风险之间的关联。方法 使用 cox 模型评估来自英国生物样本库的 84 453 例糖尿病前期和糖尿病患者，并进行 12 年随访，评估 HGS 与糖尿病并发症之间的关联。在广州糖尿病眼研究 （GDES） 的 819 名糖尿病患者中评估了 HGS 与纵向微循环损伤率之间的关联，并进行了 3 年随访。参与者被分为三个年龄组 （<56、56-65 和 ≥65 岁），每组进一步细分为三个 HGS 三分位数。结果 HGS 减少 5 kg 与全因死亡风险增加相关 （女性，HR=1.10,95% CI：1.05 至 1.14;p<0.001;男性，HR=1.13,95% CI：1.11 至 1.15;p<0.001）。与最高 HGS 组相比，HGS 最低组的女性和男性患心肌梗死和中风的风险分别高 1.6 倍和 1.3-1.5 倍。在男性中，发生终末期肾病的风险更高 （HR=1.83,95% CI： 1.30 至 2.57;p=0.001），而在女性中未观察到这种情况。与最高 HGS 组相比，HGS 最低组的两性患糖尿病视网膜病变的风险都高 1.3 倍。在 GDES 组中，HGS 最低的个体表现出视网膜微循环损伤加速 （均 p<0.05）。结论 HGS 降低与糖尿病并发症和加速微血管损伤的风险增加显著相关。HGS 可以作为糖尿病前期和糖尿病患者血管健康的实用指标。没有可用的数据。