White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status,Alzheimer's & Dementia

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White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-18 , DOI: 10.1002/alz.14408
Kyle C Kern _{1,

2} , Manu Vohra ₁ , Marissa L Thirion ₁ , Danny J J Wang ₃ , Donna M Wilcock ₄ , Jeffrey F Thompson ₅ , Gary A Rosenberg ₅ , Abhay Sagare ₆ , Abhay Moghekar ₇ , Hanzhang Lu ₇ , Tiffany Lee ₄ , Fanny M Elahi ₈ , Claudia L Satizabal ₉ , Russell Tracy ₁₀ , Sudha Seshadri ₉ , Kristin Schwab ₁₁ , Karl Helmer ₁₁ , Herpreet Singh ₁₁ , Pia Kivisäkk ₁₁ , Steven M Greenberg ₁₁ , Keith Vossel ₁ , Joel H Kramer ₁₂ , Pauline Maillard ₁₃ , Charles S DeCarli ₁₃ , Jason D Hinman _{1,

2}

Affiliation

Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.
Department of Neurology, West Los Angeles Veterans Affairs Medical Center, Los Angeles, California, USA.
Departments of Neurology and Radiology, University of Southern California, SHN, Los Angeles, California, USA.
Sanders-Brown Center on Aging, Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Center for Memory and Aging, Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.
Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, Department of Population Health Sciences, UT Health San Antonio, San Antonio, Texas, USA.
Departments of Biochemistry and Pathology & Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
Memory and Aging Center, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, California, USA.
Department of Neurology, University of California Davis, Davis, California, USA.

Placental growth factor (PlGF) may regulate cerebrovascular permeability. We hypothesized that white matter interstitial fluid accumulation, estimated via magnetic resonance imaging (MRI) free water (FW), would explain the associations between elevated PlGF, white matter hyperintensities (WMH), and cognitive impairment.

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