Background Phenotypic age acceleration (PhenoAgeAccel) is a potential aging biomarker. While weekend catch-up sleep (WCS) is commonly practiced to compensate for weekday sleep deficits, its relationship with PhenoAgeAccel remains unclear. Methods In this cross-sectional study, we analyzed data from 7,683 participants in the National Health and Nutrition Examination Survey (NHANES). WCS duration was calculated as weekend sleep duration minus weekday sleep duration, and WCS was further defined as WCS duration >0 h. Multivariable logistic regression adjusted for confounders and subgroup analyses by weekday sleep duration were employed to examine the relationship of WCS with PhenoAgeAccel. Results WCS is associated with a modulated risk of PhenoAgeAccel, contingent on the amount of WCS and regular weekday sleep. Specifically, engaging in 0–1 hour of WCS was associated with significantly lower odds of PhenoAgeAccel (Odds Ratio [OR] = 0.80, 95% Confidence Interval [CI]: 0.68, 0.94, p = 0.007) compared to no WCS, particularly among individuals who averaged 7–8 hours of sleep on weekdays (OR = 0.67, 95% CI: 0.49, 0.93, p = 0.016). Conversely, those sleeping less than 6 hours on weekdays benefited from extending WCS beyond 2 hours (OR = 0.65, 95% CI: 0.44, 0.97, p = 0.036). No benefits were observed for those with more than 8 hours of weekday sleep. Conclusions WCS is associated with a reduced likelihood of PhenoAgeAccel among individuals with inadequate weekday sleep, particularly those sleeping less than 6 hours or between 7 to 8 hours on weekdays.

中文翻译：

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检查周末补觉与表型年龄加速之间的关系：来自横断面研究的见解


背景 表型年龄加速 （PhenoAgeAccel） 是一种潜在的衰老生物标志物。虽然周末补觉 （WCS） 通常用于补偿工作日的睡眠不足，但它与 PhenoAgeAccel 的关系仍不清楚。方法 在这项横断面研究中，我们分析了全国健康和营养检查调查 （NHANES） 中 7,683 名参与者的数据。WCS 持续时间计算为周末睡眠持续时间减去工作日睡眠持续时间，WCS 进一步定义为 WCS 持续时间 >0 h。采用针对混杂因素调整的多变量 logistic 回归和按工作日睡眠持续时间进行亚组分析来检查 WCS 与 PhenoAgeAccel 的关系。结果 WCS 与 PhenoAgeAccel 的调节风险相关，具体取决于 WCS 的数量和工作日的规律睡眠。具体来说，与没有 WCS 相比，参与 0-1 小时的 WCS 与 PhenoAgeAccel 的几率显著降低相关（比值比 [OR] = 0.80,95% 置信区间 [CI]：0.68,0.94，p = 0.007），特别是在工作日平均睡眠 7-8 小时的个体中 （OR = 0.67,95% CI：0.49,0.93，p = 0.016）。相反，那些工作日睡眠时间少于 6 小时的人受益于将 WCS 延长到 2 小时以上 （OR = 0.65,95% CI： 0.44,0.97，p = 0.036）。对于工作日睡眠时间超过 8 小时的人，没有观察到任何益处。结论 WCS 与工作日睡眠不足个体发生 PhenoAgeAccel 的可能性降低相关，尤其是那些工作日睡眠时间少于 6 小时或 7 至 8 小时的人。