Examining the relationship between weekend catch-up sleep and phenotypic age acceleration: Insights from a cross-sectional study,The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

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Examining the relationship between weekend catch-up sleep and phenotypic age acceleration: Insights from a cross-sectional study
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2024-12-19 , DOI: 10.1093/gerona/glae295
Dongmei Liu, Chen Wang, Ben Huang, Jun Qiu, Zheng Zhang

Background Phenotypic age acceleration (PhenoAgeAccel) is a potential aging biomarker. While weekend catch-up sleep (WCS) is commonly practiced to compensate for weekday sleep deficits, its relationship with PhenoAgeAccel remains unclear. Methods In this cross-sectional study, we analyzed data from 7,683 participants in the National Health and Nutrition Examination Survey (NHANES). WCS duration was calculated as weekend sleep duration minus weekday sleep duration, and WCS was further defined as WCS duration >0 h. Multivariable logistic regression adjusted for confounders and subgroup analyses by weekday sleep duration were employed to examine the relationship of WCS with PhenoAgeAccel. Results WCS is associated with a modulated risk of PhenoAgeAccel, contingent on the amount of WCS and regular weekday sleep. Specifically, engaging in 0–1 hour of WCS was associated with significantly lower odds of PhenoAgeAccel (Odds Ratio [OR] = 0.80, 95% Confidence Interval [CI]: 0.68, 0.94, p = 0.007) compared to no WCS, particularly among individuals who averaged 7–8 hours of sleep on weekdays (OR = 0.67, 95% CI: 0.49, 0.93, p = 0.016). Conversely, those sleeping less than 6 hours on weekdays benefited from extending WCS beyond 2 hours (OR = 0.65, 95% CI: 0.44, 0.97, p = 0.036). No benefits were observed for those with more than 8 hours of weekday sleep. Conclusions WCS is associated with a reduced likelihood of PhenoAgeAccel among individuals with inadequate weekday sleep, particularly those sleeping less than 6 hours or between 7 to 8 hours on weekdays.

更新日期：2024-12-19

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