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Tau pathway-based gene analysis on PET identifies CLU and FYN in a Korean cohort
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-03 , DOI: 10.1002/alz.14416 Dahyun Yi, Min Soo Byun, Jong-Ho Park, Jong-Won Kim, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Shiwei Liu, Yen-Ning Huang, Andrew J. Saykin, Dong Young Lee, Kwangsik Nho
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-03 , DOI: 10.1002/alz.14416 Dahyun Yi, Min Soo Byun, Jong-Ho Park, Jong-Won Kim, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Shiwei Liu, Yen-Ning Huang, Andrew J. Saykin, Dong Young Lee, Kwangsik Nho
The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer's disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene association analysis in a Korean cohort.
中文翻译:
基于 Tau 通路的 PET 基因分析在韩国队列中识别 CLU 和 FYN
遗传变异对 tau 蛋白聚集的影响是阿尔茨海默病 (AD) 的一个关键因素,目前尚不完全清楚。我们旨在使用基于通路的候选基因关联分析在韩国队列中鉴定与脑 tau 沉积相关的新基因。
更新日期:2024-12-03
中文翻译:
基于 Tau 通路的 PET 基因分析在韩国队列中识别 CLU 和 FYN
遗传变异对 tau 蛋白聚集的影响是阿尔茨海默病 (AD) 的一个关键因素,目前尚不完全清楚。我们旨在使用基于通路的候选基因关联分析在韩国队列中鉴定与脑 tau 沉积相关的新基因。