Background We assessed the association of adherence to the guidelines and subsequent changes over time in adherence with all-cause mortality. Methods We used data from 3518 and 3273 older adults, aged 60-96 years at baseline, from Seniors-ENRICA-1 and 2 cohorts, respectively. Adherence to 24-hour movement guidelines was defined as ≥150 minutes/week of moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB) ≤8 hours/day (including ≤3 hours/day of recreational screen time), and 7-9 hours/day of sleep if aged 18-64y or 7-8 hours/day if aged ≥65y. All-cause mortality was ascertained up to January 31, 2024. Analyses were performed using Cox regression adjusted for the main confounders. Results Of the 6613 participants with complete data, 1353 died during a mean follow-up of 10.1 (SD = 4.0) years. Meeting MVPA (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.65-0.82), SB (HR 0.89; 95% CI 0.80-0.99), and sleep (HR 0.89; 95% CI 0.80-0.99) recommendations were associated with lower mortality. Also, we noticed a reduction in mortality in meeting MVPA combined with both SB (34%) and sleep (12%), sleep and SB combined (23%), and meeting all 24-hour movement guidelines (40%). Changes in meeting 24-hour movement guidelines occurred between a mean follow-up of 2.8 (0.6) years. Meeting 24-hour movement guidelines at baseline and follow-up is associated with lower mortality (HR 0.69; 95% CI 0.47-0.99), compared to not meet them at both examinations. Conclusions This prospective cohort study underscores the critical impact of adhering to and maintaining adherence to the 24-hour movement guidelines in reducing mortality risk among older adults.

中文翻译：

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满足老年人 24 小时运动指南和死亡风险：老年人-ENRICA 队列的横断面和纵向汇总分析


背景 我们评估了对指南的依从性以及随后随时间变化与全因死亡率的相关性。方法 我们使用了 3518 名和 3273 名老年人的数据，基线时年龄在 60-96 岁之间，分别来自 Seniors-ENRICA-1 和 2 队列。遵守 24 小时运动指南定义为每周 ≥150 分钟的中等至剧烈体育活动 （MVPA）、久坐行为 （SB） ≤8 小时/天（包括 ≤3 小时/天的娱乐屏幕时间）和 7-9 小时/天的睡眠（如果年龄为 18-64 岁）或 7-8 小时/天（如果年龄为 ≥65）。截至 2024 年 1 月 31 日的全因死亡率已确定。使用针对主要混杂因素进行调整的 Cox 回归进行分析。结果 在数据完整的 6613 名参与者中，1353 名在平均随访 10.1 （SD = 4.0） 年期间死亡。满足 MVPA （风险比 [HR] 0.73;95% 置信区间 [CI] 0.65-0.82）、SB （HR 0.89;95% CI 0.80-0.99） 和睡眠 （HR 0.89;95% CI 0.80-0.99） 建议与较低的死亡率相关。此外，我们注意到，在满足 MVPA 联合 SB （34%） 和睡眠 （12%）、睡眠和 SB 联合 （23%） 以及满足所有 24 小时运动指南 （40%） 时，死亡率降低。满足 24 小时运动指南的变化发生在平均 2.8 （0.6） 年之间。与在两项检查中均未达到 24 小时运动指南相比，在基线和随访时满足 24 小时运动指南与较低的死亡率相关 （HR 0.69;95% CI 0.47-0.99）。结论 这项前瞻性队列研究强调了坚持和保持 24 小时运动指南对降低老年人死亡风险的关键影响。