Single-microglia transcriptomic transition network-based prediction and real-world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease,Alzheimer's & Dementia

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Single-microglia transcriptomic transition network-based prediction and real-world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-06 , DOI: 10.1002/alz.14373
Jielin Xu _{1,

2} , Wenqiang Song ₁ , Zhenxing Xu _{3,

4} , Michael M Danziger ₅ , Ehud Karavani ₅ , Chengxi Zang _{3,

4} , Xin Chen _{1,

2} , Yichen Li _{1,

2} , Isabela M Rivera Paz ₂ , Dhruv Gohel _{1,

2} , Chang Su _{3,

4} , Yadi Zhou _{1,

2} , Yuan Hou _{1,

2} , Yishai Shimoni ₅ , Andrew A Pieper _{6,

7,

8,

9,

10} , Jianying Hu ₁₁ , Fei Wang _{3,

4} , Michal Rosen-Zvi ₅ , James B Leverenz ₁₂ , Jeffrey Cummings ₁₃ , Feixiong Cheng _{1,

2,

14}

Affiliation

Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, New York, USA.
AI for Accelerated Healthcare and Life Sciences Discovery, IBM Research-Israel, Haifa, Israel.
Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA.
Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA.
IBM T.J. Watson Research Center, Yorktown Heights, New York, USA.
Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.