当前位置：
X-MOL 学术
›
Alzheimers Dement.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Biological brain age and resilience in cognitively unimpaired 70‐year‐old individuals
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-20 , DOI: 10.1002/alz.14435 Anna Marseglia, Caroline Dartora, Jessica Samuelsson, Konstantinos Poulakis, Rosaleena Mohanty, Sara Shams, Olof Lindberg, Lina Rydén, Therese Rydberg Sterner, Johan Skoog, Anna Zettergren, Silke Kern, Ingmar Skoog, Eric Westman
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-12-20 , DOI: 10.1002/alz.14435 Anna Marseglia, Caroline Dartora, Jessica Samuelsson, Konstantinos Poulakis, Rosaleena Mohanty, Sara Shams, Olof Lindberg, Lina Rydén, Therese Rydberg Sterner, Johan Skoog, Anna Zettergren, Silke Kern, Ingmar Skoog, Eric Westman
INTRODUCTIONThis study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function.METHODSWe derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.RESULTSGreater BAG (older‐looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger‐looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white‐matter alterations, inflammation, high glucose, poorer vascular‐related cognitive domains. Sex‐specific associations were identified.DISCUSSIONVascular‐related lifestyles and health shape brain appearance. Inflammation and insulin‐related processes may be keys to understanding vascular cognitive disorders.Highlights BAG, reflecting deviations from CA, can indicate resilience. Diabetes, stroke, and low physical activity link to “older” brains (greater BAG). Physical activity yielded to “younger” brains in septuagenarians with obesity. High cerebrovascular burden, inflammation, and glucose associate with “older” brains. Sex differences were detected in all BAG‐associated factors.
更新日期：2024-12-20
京公网安备 11010802027423号