INTRODUCTIONWe evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all‐cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow‐up in the community‐based Framingham Heart Study Offspring cohort.METHODSOne thousand four hundred eighty‐seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all‐cause dementia and AD surveillance data available.RESULTSTwo hundred forty‐six participants developed all‐cause dementia (including AD, n = 187) over a median follow‐up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all‐cause dementia and AD after adjustment for demographic, lifestyle, and clinical covariates (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.10–1.33, P < 0.001; HR 1.20, 95% CI: 1.07–1.34d, P = 0.001, respectively).DISCUSSIONHigher DII scores were associated with a higher risk of incident all‐cause dementia and AD. Although these promising findings need to be replicated and further validated, our results suggest that diets that correlate with low DII scores may prevent late‐life dementia.Highlights Higher Dietary Inflammatory Index (DII) scores were associated with an increased incidence of all‐cause dementia. Higher DII scores were associated with an increased incidence of Alzheimer's disease dementia. Diets that correlate with low DII scores may prevent late‐life dementia.

中文翻译：

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饮食炎症指数评分与痴呆事件之间的关联


引言我们评估了在以社区为基础的弗雷明汉心脏研究后代队列中 22.3 年的随访中，较高的饮食炎症指数 （DII） 评分是否与全因痴呆和阿尔茨海默病 （AD） 痴呆的发生率增加有关。方法共有 487 名参与者 （平均±标准差，年龄在 69 ± 6 岁之间）完成了食物频率问卷 （FFQ），并获得了事件全因 痴呆 和 AD 监测数据。结果246 名参与者在中位随访时间为 13.1 年期间发展为全因痴呆 （包括 AD，n = 187）。在调整人口统计学、生活方式和临床协变量后，较高的 DII 评分（最多三个时间点的平均值）与全因痴呆和 AD 的发生率增加相关（风险比 [HR] 1.21,95% 置信区间 [CI] 1.10-1.33，P < 0.001;HR 1.20,95% CI：1.07–1.34d，P = 0.001）。讨论较高的 DII 评分与发生全因痴呆和 AD 的风险较高相关。尽管这些有希望的发现需要复制和进一步验证，但我们的研究结果表明，与低 DII 评分相关的饮食可以预防晚年痴呆。亮点 较高的饮食炎症指数 （DII） 评分与全因痴呆的发生率增加有关。较高的 DII 评分与阿尔茨海默病痴呆发病率增加相关。与低 DII 评分相关的饮食可以预防晚年痴呆。