Background and Hypothesis Schizophrenia is a severe mental disorder that has a significant impact on quality of life (QOL). Measuring QOL can offer insights into treatment efficacy and areas of intervention, highlighting the importance of valid tools assessing QOL in people with schizophrenia. Study Design We employed the COSMIN systematic review guideline to assess the psychometric properties of the schizophrenia quality of life scale (SQLS) and its 4th revision, the schizophrenia quality of life scale revision 4 (SQLS-R4), as patient-reported outcome measures (PROMs). Study Results The search yielded 455 papers, 16 were included, 7 for the SQLS and 9 for the SQLS-R4. Both scales demonstrated good results in risk of bias assessment for internal consistency and convergent validity, the SQLS-R4 additionally for known-groups validity. For the SQLS, PROM development, structural validity, and reliability were suboptimal. The SQLS-R4 showed suboptimality regarding structural validity and reliability and inadequacy for cross-cultural validity and responsiveness. The updated criteria for good measurement properties indicated good convergent validity for the SQLS and good internal consistency, reliability, and convergent validity for the SQLS-R4. The SQLS showed suboptimal results for reliability and known-groups validity, while the SQLS-R4 demonstrated suboptimality in structural validity and known-groups validity. The SQLS had indeterminate structural validity and internal consistency; the SQLS-R4 showed indeterminate responsiveness, and insufficient cross-cultural validity. When using the updated GRADE approach of the COSMIN group, both scales received a very low grade. Conclusions The SQLS and SQLS-R4 hold the potential for recommendation in rating QOL. Identified weaknesses necessitate further validations.

中文翻译：

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精神分裂症生活质量量表和精神分裂症生活质量量表修订版 4：测量属性的系统回顾


背景和假设 精神分裂症是一种严重的精神障碍，对生活质量（QOL）有重大影响。测量生活质量可以深入了解治疗效果和干预领域，强调评估精神分裂症患者生活质量的有效工具的重要性。研究设计 我们采用 COSMIN 系统评价指南来评估精神分裂症生活质量量表 (SQLS) 及其第四次修订版精神分裂症生活质量量表修订版 4 (SQLS-R4) 的心理测量特性，作为患者报告的结果测量（ PROM）。研究结果 检索出 455 篇论文，其中纳入 16 篇，其中 7 篇涉及 SQLS，9 篇涉及 SQLS-R4。两种量表在内部一致性和收敛效度的偏倚风险评估方面都表现出良好的结果，SQLS-R4 另外在已知群体的效度方面也表现出良好的结果。对于 SQLS，PROM 开发、结构有效性和可靠性都不是最优的。 SQLS-R4 在结构有效性和可靠性方面表现出次优，在跨文化有效性和响应性方面表现出不足。良好测量属性的更新标准表明 SQLS 具有良好的收敛有效性，而 SQLS-R4 具有良好的内部一致性、可靠性和收敛有效性。 SQLS 在可靠性和已知组有效性方面表现出次优结果，而 SQLS-R4 在结构有效性和已知组有效性方面表现出次优结果。 SQLS具有不确定的结构有效性和内部一致性； SQLS-R4 显示出不确定的响应能力，并且跨文化有效性不足。当使用 COSMIN 小组更新的 GRADE 方法时，两个量表的评分都非常低。结论 SQLS 和 SQLS-R4 在 QOL 评级方面具有推荐潜力。 已发现的弱点需要进一步验证。