Background and Hypothesis For a long time, it was proposed that schizophrenia (SCZ) patients rely more on sensory input and less on prior information, potentially leading to reduced serial dependence—ie, a reduced influence of prior stimuli in perceptual tasks. However, existing evidence is constrained to a few paradigms, and whether reduced serial dependence reflects a general characteristic of the disease remains unclear. Study Design We investigated serial dependence in 26 SCZ patients and 27 healthy controls (CNT) to evaluate the influence of prior stimuli in a classic visual orientation adjustment task, a paradigm not previously tested in this context. Study Results As expected, the CNT group exhibited clear serial dependence, with systematic biases toward the orientation of stimuli shown in the preceding trials. Serial dependence in SCZ patients was largely comparable to that in the CNT group. Conclusions These findings challenge the prevailing notion of reduced serial dependence in SCZ, suggesting that observed differences between healthy CNT and patients may depend on aspects of perceptual or cognitive processing that are currently not understood.

中文翻译：

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精神分裂症中的完整序列依赖性：来自定向调整任务的证据


背景和假设长期以来，人们提出精神分裂症 （SCZ） 患者更多地依赖感觉输入，而不是先验信息，这可能导致序列依赖性减少——即先前刺激对感知任务的影响减少。然而，现有证据仅限于少数范例，减少的序列依赖性是否反映了该疾病的一般特征仍不清楚。研究设计 我们调查了 26 名 SCZ 患者和 27 名健康对照 （CNT） 的连续依赖性，以评估先前刺激在经典视觉方向调整任务中的影响，这种范式以前没有在这种情况下测试过。研究结果 正如预期的那样，CNT 组表现出明显的序列依赖性，在之前的试验中显示出对刺激方向的系统性偏倚。SCZ 患者的连续依赖性与 CNT 组基本相当。结论这些发现挑战了 SCZ 中减少序列依赖性的流行观念，表明观察到的健康 CNT 和患者之间的差异可能取决于目前尚不清楚的感知或认知处理方面。