Background and Hypothesis For a long time, it was proposed that schizophrenia (SCZ) patients rely more on sensory input and less on prior information, potentially leading to reduced serial dependence—ie, a reduced influence of prior stimuli in perceptual tasks. However, existing evidence is constrained to a few paradigms, and whether reduced serial dependence reflects a general characteristic of the disease remains unclear. Study Design We investigated serial dependence in 26 SCZ patients and 27 healthy controls (CNT) to evaluate the influence of prior stimuli in a classic visual orientation adjustment task, a paradigm not previously tested in this context. Study Results As expected, the CNT group exhibited clear serial dependence, with systematic biases toward the orientation of stimuli shown in the preceding trials. Serial dependence in SCZ patients was largely comparable to that in the CNT group. Conclusions These findings challenge the prevailing notion of reduced serial dependence in SCZ, suggesting that observed differences between healthy CNT and patients may depend on aspects of perceptual or cognitive processing that are currently not understood.

中文翻译：

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精神分裂症的完整序列依赖性：来自方向调整任务的证据


背景和假设 长期以来，有人提出精神分裂症（SCZ）患者更多地依赖感觉输入，而不是先验信息，这可能会导致序列依赖性的减少，即感知任务中先验刺激的影响减少。然而，现有证据仅限于少数范式，并且序列依赖性的减少是否反映了该疾病的一般特征仍不清楚。研究设计 我们研究了 26 名 SCZ 患者和 27 名健康对照 (CNT) 的序列依赖性，以评估先前刺激对经典视觉方向调整任务的影响，这是之前未在这种情况下测试过的范例。研究结果 正如预期的那样，CNT 组表现出明显的序列依赖性，对先前试验中显示的刺激方向存在系统偏差。 SCZ 患者的连续依赖性在很大程度上与 CNT 组相当。结论 这些发现挑战了 SCZ 序列依赖性减少的普遍观念，表明健康 CNT 和患者之间观察到的差异可能取决于目前尚不了解的知觉或认知处理方面。