Background Negative symptoms of schizophrenia are correlated with reduction of normal function and lower quality of life. They were newly defined by the NIMH-MATRICS Consensus in 2005, dividing the rating tools to assess them into first-generation scales, developed before the Consensus, and second-generation scales, based on the recently introduced definitions. Methods The COnsensus-based Standards for the selection of health Measurement Instrument (COSMIN) guidelines for systematic reviews were used to evaluate the quality of psychometric data of the first-generation scales that cover the 5 negative symptom domains of the NIMHS Consensus: the Scale for the Assessment of Negative Symptoms (SANS), the High Royds Evaluation of Negativity Scale (HEN), and the Negative Symptom Assessment-16 (NSA-16). Results The search strategy resulted in the inclusion of a total of 13 articles, 7 for the SANS, 4 for the NSA-16, and 2 for the HEN. For the SANS and the NSA-16, the overall results of the scales’ measurement properties are mostly insufficient or indeterminate. The quality of evidence for the HEN is poor, due to a small number of validation studies/included patients. Conclusions After applying the COSMIN guidelines, we do not recommend the usage of these first-generation scales to rate negative symptoms. At the minimum they require further validation.

中文翻译：

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临床医生报告的阴性症状量表：测量特性的系统评价


背景 精神分裂症的阴性症状与正常功能下降和生活质量降低有关。它们是 2005 年 NIMH-MATRICS 共识新定义的，根据最近引入的定义，将评估它们的评级工具分为在共识之前开发的第一代量表和第二代量表。方法 基于 COnsensus 的健康测量工具选择标准 （COSMIN） 系统评价指南用于评估涵盖 NIMHS 共识的 5 个负面症状领域的第一代量表的心理测量数据的质量：阴性症状评估量表 （SANS）、高 Royds 消极评价量表 （HEN）、 和阴性症状评估 16 （NSA-16）。结果 检索策略共纳入 13 篇文章，其中 7 篇为 SANS，4 篇为 NSA-16,2 篇为 HEN。对于 SANS 和 NSA-16，秤测量特性的总体结果大多不充分或不确定。由于验证研究/纳入的患者数量少，HEN 的证据质量较差。结论 应用 COSMIN 指南后，我们不建议使用这些第一代量表来评估阴性症状。至少，它们需要进一步的验证。