Regional Structural-Functional Connectivity Coupling in Major Depressive Disorder Is Associated With Neurotransmitter and Genetic Profiles,Biological Psychiatry

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Regional Structural-Functional Connectivity Coupling in Major Depressive Disorder Is Associated With Neurotransmitter and Genetic Profiles
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-08-30 , DOI: 10.1016/j.biopsych.2024.08.022
Tongpeng Chu ₁ , Xiaopeng Si ₂ , Haizhu Xie ₃ , Heng Ma ₃ , Yinghong Shi ₃ , Wei Yao ₄ , Dong Xing ₃ , Feng Zhao ₅ , Fanghui Dong ₃ , Qun Gai ₃ , Kaili Che ₃ , Yuting Guo ₆ , Danni Chen ₆ , Dong Ming ₂ , Ning Mao ₇

Affiliation

Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China, 300072; Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China, 264000; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin, China, 300072; Haihe Laboratory of Brain-computer Interaction and Human-machine Integration, Tianjin, China, 300392; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin University, Tianjin, China, 300072; Shandong Provincial Key Medical and Health Laboratory of Intelligent Diagnosis and Treatment for Women's Diseases (Yantai Yuhuangding Hospital); Big Data and Artificial Intelligence Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China, 264000.
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China, 300072; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin, China, 300072; Haihe Laboratory of Brain-computer Interaction and Human-machine Integration, Tianjin, China, 300392; Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin University, Tianjin, China, 300072.
Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China, 264000.
Department of Neurology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, P. R. China, 253000.
School of Computer Science and Technology, Shandong Technology and Business University, Yantai, Shandong, P. R. China, 264000.
School of Medical Imaging, Binzhou Medical University, Yantai, Shandong, P. R. China, 264000.
Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China, 264000; Shandong Provincial Key Medical and Health Laboratory of Intelligent Diagnosis and Treatment for Women's Diseases (Yantai Yuhuangding Hospital); Big Data and Artificial Intelligence Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China, 264000.

Abnormalities in structural-functional connectivity (SC-FC) coupling have been identified globally in patients with major depressive disorder (MDD). However, investigations have neglected the variability and hierarchical distribution of these abnormalities across different brain regions. Furthermore, the biological mechanisms that underlie regional SC-FC coupling patterns are not well understood.

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