Alterations in the effects of glucocorticoids have been implicated in mediating some of the negative health effects associated with chronic stress, including increased risk for psychiatric disorders and cardiovascular and metabolic diseases. In this study, we investigated how genetic variants influence gene expression and DNA methylation in response to glucocorticoid receptor (GR) activation and their association with disease risk.

中文翻译：

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对糖皮质激素的分子反应的多组学分析：从精神疾病到医学疾病的共同遗传风险的见解


糖皮质激素作用的改变与介导与慢性压力相关的一些负面健康影响有关，包括增加患精神疾病以及心血管和代谢疾病的风险。在这项研究中，我们研究了遗传变异如何影响响应糖皮质激素受体 （GR） 激活的基因表达和 DNA 甲基化及其与疾病风险的关系。