Neuropsychiatric symptoms, such as depression and anxiety, are observed in 90% of patients with Alzheimer’s disease (AD), two-thirds of whom are women. Neuropsychiatric symptoms usually manifest long before AD onset creating a therapeutic opportunity. Here, we examined the impact of anxiety on AD progression and the underlying brainwide neuronal mechanisms.

中文翻译：

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焦虑对认知和活动依赖神经网络的性别特异性影响：来自（雌性）小鼠和（女性）男性的见解


在 90% 的阿尔茨海默病 （AD） 患者中观察到神经精神症状，例如抑郁和焦虑，其中三分之二是女性。神经精神症状通常在 AD 发作之前很久就表现出来，从而创造了治疗机会。在这里，我们研究了焦虑对 AD 进展的影响和潜在的全脑神经元机制。