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Corticotropin-Releasing Factor Release From a Unique Subpopulation of Accumbal Neurons Constrains Action-Outcome Acquisition in Reward Learning
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-08-22 , DOI: 10.1016/j.biopsych.2024.08.006
Elizabeth A. Eckenwiler, Anna E. Ingebretson, Jeffrey J. Stolley, Maxine A. Fusaro, Alyssa M. Romportl, Jack M. Ross, Christopher L. Petersen, Eera M. Kale, Michael S. Clark, Selena S. Schattauer, Larry S. Zweifel, Julia C. Lemos

The nucleus accumbens (NAc) mediates reward learning and motivation. Despite an abundance of neuropeptides, peptidergic neurotransmission from the NAc has not been integrated into current models of reward learning. The existence of a sparse population of neurons containing corticotropin-releasing factor (CRF) has been previously documented. Here, we provide a comprehensive analysis of their identity and functional role in shaping reward learning.

中文翻译:


来自累积神经元独特亚群的促肾上腺皮质激素释放因子抑制了奖励学习中的动作结果获取



伏隔核 (NAc) 介导奖励学习和动机。尽管有丰富的神经肽,但来自 NAc 的肽能神经传递尚未整合到当前的奖励学习模型中。先前已经记录了存在稀疏的含有促肾上腺皮质激素释放因子 (CRF) 的神经元群。在这里,我们全面分析了他们的身份和功能作用在塑造奖励学习中的作用。
更新日期:2024-08-22
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