Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses.

中文翻译：

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重度抑郁症的星形胶质细胞基础：分子、细胞和回路特征


重度抑郁症是一种常见的精神疾病，也是世界范围内导致残疾的主要原因。星形胶质细胞在维持中枢神经系统的功能中发挥作用，包括生理和病理。积累的证据表明，星形胶质细胞是重度抑郁症病理生理学的重要贡献者，包括血脑屏障完整性、间隙连接、神经胶质传递、谷氨酸稳态和能量代谢。在这里，我们基于分子、细胞和回路特性全面总结了重度抑郁症的星形胶质细胞基础，表明星形胶质细胞似乎对压力高度敏感，并且可能具有整合外周和中枢应激反应的独特位置。