Unique Functional Neuroimaging Signatures of Genetic Versus Clinical High Risk for Psychosis,Biological Psychiatry

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Unique Functional Neuroimaging Signatures of Genetic Versus Clinical High Risk for Psychosis
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-08-23 , DOI: 10.1016/j.biopsych.2024.08.010
Charles H Schleifer ₁ , Sarah E Chang ₁ , Carolyn M Amir ₁ , Kathleen P O'Hora ₁ , Hoki Fung ₁ , Jee Won D Kang ₂ , Leila Kushan-Wells ₁ , Eileen Daly ₃ , Fabio Di Fabio ₄ , Marianna Frascarelli ₄ , Maria Gudbrandsen ₅ , Wendy R Kates ₆ , Declan Murphy ₃ , Jean Addington ₇ , Alan Anticevic ₈ , Kristin S Cadenhead ₉ , Tyrone D Cannon ₈ , Barbara A Cornblatt ₁₀ , Matcheri Keshavan ₁₁ , Daniel H Mathalon ₁₂ , Diana O Perkins ₁₃ , William Stone ₁₁ , Elaine Walker ₁₄ , Scott W Woods ₈ , Lucina Q Uddin ₁ , Kuldeep Kumar ₁₅ , Gil D Hoftman ₁ , Carrie E Bearden ₁₆

Affiliation

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Department of Psychology, University of California, Los Angeles, CA, USA.
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK.
Department of Human Neurosciences, Sapienza University, Rome, Italy.
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK; Centre for Psychological Research (CREW), School of Psychology, University of Roehampton, London, UK.
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Departments of Psychology and Psychiatry, Yale University, New Haven, CT, USA.
Department of Psychiatry, University of California, San Diego, CA, USA.
Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Department of Psychiatry, University of California, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Department of Psychology, Emory University, Atlanta, GA, USA.
Centre de Recherche du CHU Sainte-Justine, University of Montreal, Montreal, Canada.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA; Department of Psychology, University of California, Los Angeles, CA, USA.

22q11.2 deletion syndrome (22qDel) is a copy number variant that is associated with psychosis and other neurodevelopmental disorders. Adolescents who are at clinical high risk for psychosis (CHR) are identified based on the presence of subthreshold psychosis symptoms. Whether common neural substrates underlie these distinct high-risk populations is unknown. We compared functional brain measures in 22qDel and CHR cohorts and mapped the results to biological pathways.

中文翻译：

遗传与临床精神病高风险的独特功能神经影像学特征

22q11.2 缺失综合征（22qDel）是一种与精神病和其他神经发育障碍相关的拷贝数变体。临床上精神病（CHR）高风险的青少年根据是否存在阈下精神病症状来识别。这些不同的高危人群是否具有共同的神经底物尚不清楚。我们比较了 22qDel 和 CHR 队列中的大脑功能测量，并将结果映射到生物通路。

更新日期：2024-08-23

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