Effect of Antidepressant Treatment on 5-HT4 Receptor Binding and Associations With Clinical Outcomes and Verbal Memory in Major Depressive Disorder,Biological Psychiatry

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Effect of Antidepressant Treatment on 5-HT4 Receptor Binding and Associations With Clinical Outcomes and Verbal Memory in Major Depressive Disorder
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-08-22 , DOI: 10.1016/j.biopsych.2024.08.009
Vibeke H Dam ₁ , Kristin Köhler-Forsberg ₂ , Brice Ozenne ₃ , Søren V Larsen ₁ , Cheng Teng Ip ₄ , Anders Jorgensen ₅ , Dea S Stenbæk ₆ , Jacob Madsen ₇ , Claus Svarer ₈ , Martin B Jørgensen ₂ , Gitte M Knudsen ₁ , Vibe G Frokjaer ₂

Affiliation

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Psychiatric Center Copenhagen, Copenhagen, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark; Department of Public Health, Section of Biostatistics, University of Copenhagen, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Center for Cognitive and Brain Sciences, University of Macau, Taipa Macau SAR, China.
Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Psychiatric Center Copenhagen, Copenhagen, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark; Department of Psychology, University of Copenhagen, Denmark.
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark.

Brain serotonin 4 receptor (5-HT4R) levels are lower in untreated patients with major depressive disorder (MDD) and are linked to verbal memory. Here, we investigated the relationship between 5-HT4R levels, clinical outcomes, and cognitive function in patients with MDD who initiated selective serotonin reuptake inhibitor drug treatment.

中文翻译：

抗抑郁药治疗对重度抑郁症 5-HT4 受体结合的影响及其与临床结局和语言记忆的相关性

未经治疗的重度抑郁症（MDD）患者的脑血清素 4 受体（5-HT4R）水平较低，并且与语言记忆有关。在这里，我们研究了开始选择性 5-羟色胺再摄取抑制剂药物治疗的 MDD 患者 5-HT4R 水平、临床结果和认知功能之间的关系。

更新日期：2024-08-22

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