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Data-driven analysis identifies novel modulation of social behavior in female mice witnessing chronic social defeat stress
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-12-03 , DOI: 10.1016/j.biopsych.2024.11.017 Heike Schuler, Rand S. Eid, Serena Wu, Yiu-Chung Tse, Vedrana Cvetkovska, Joëlle Lopez, Rosalie Quinn, Delong Zhou, Juliet Meccia, Laurence Dion-Albert, Shannon N. Bennett, Emily L. Newman, Brian C. Trainor, Catherine J. Peña, Caroline Menard, Rosemary C. Bagot
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-12-03 , DOI: 10.1016/j.biopsych.2024.11.017 Heike Schuler, Rand S. Eid, Serena Wu, Yiu-Chung Tse, Vedrana Cvetkovska, Joëlle Lopez, Rosalie Quinn, Delong Zhou, Juliet Meccia, Laurence Dion-Albert, Shannon N. Bennett, Emily L. Newman, Brian C. Trainor, Catherine J. Peña, Caroline Menard, Rosemary C. Bagot
Chronic social defeat stress is a widely used depression model in male mice. Several proposed adaptations extend this model to females with variable, often marginal effects. We examine if the widely used male-defined metrics of stress are suboptimal in females witnessing defeat.
中文翻译:
数据驱动的分析确定了目睹慢性社交失败压力的雌性小鼠社会行为的新调节
慢性社交挫败压力是雄性小鼠中广泛使用的抑郁模型。一些提议的适应将这种模式扩展到具有可变的、通常是边际效应的雌性。我们研究了广泛使用的男性定义的压力指标在目睹失败的女性中是否次优。
更新日期:2024-12-03
中文翻译:
数据驱动的分析确定了目睹慢性社交失败压力的雌性小鼠社会行为的新调节
慢性社交挫败压力是雄性小鼠中广泛使用的抑郁模型。一些提议的适应将这种模式扩展到具有可变的、通常是边际效应的雌性。我们研究了广泛使用的男性定义的压力指标在目睹失败的女性中是否次优。