The fruits and vegetables we consume as part of our diet are rich in bioactive metabolites that can prevent and ameliorate cardiometabolic diseases, cancers, and neurological conditions. Polyphenols are a major metabolite family that has been intensively investigated in this context. However, for these compounds to exert their optimal bioactivity, they rely on the enzymatic capacity of an individual's gut microbiota. Indeed, for most polyphenols, the human host is restricted to more basic metabolism such as deglycosylation and hepatic conjugation. In this review, we discuss the mechanisms by which gut bacteria metabolize the core scaffold of polyphenol substrates, and how their conversion into bioactive small molecules impacts host health.

中文翻译：

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膳食多酚的肠道细菌代谢成生物活性化合物的机制。


我们在饮食中食用的水果和蔬菜富含生物活性代谢物，可以预防和改善心脏代谢疾病、癌症和神经系统疾病。多酚是一个主要的代谢物家族，在此背景下已进行了深入研究。然而，为了让这些化合物发挥其最佳生物活性，它们依赖于个体肠道微生物群的酶促能力。事实上，对于大多数多酚，人类宿主仅限于更基本的代谢，例如去糖基化和肝脏结合。在这篇综述中，我们讨论了肠道细菌代谢多酚底物核心支架的机制，以及它们转化为生物活性小分子如何影响宿主健康。